- Basic information
- CohesinDB ID: CDBP00417921
- Locus: chr21-34973707-34974893
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Data sourse: GSE38395, GSE93080, ENCSR167MTG, ENCSR000EAC, ENCSR000DZP, ENCSR230ZWH, GSE72082, GSE98367, ENCSR000HPG, GSE155324, ENCSR879KXD, GSE206145, ENCSR054FKH, GSE62063, ENCSR000BMY, GSE25021, GSE50893, ENCSR000EDW, ENCSR917QNE
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Cell type: GM10847, GM2610, GM19240, Liver, B-cell, GM2630, GM12890, hLCL, GM2255, IMR-90, K-562, GM18486, SNYDER, Lymphoblast, GM12878, GM12891, GM2588, GM19239, Macrophage, Ramos, GM12892, Hep-G2, GM19238
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 10% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.744
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 35%,
"7_Enh": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, HMG20A, FOXA1, PBX2, LEO1, RXRB, NFIC, RUNX3, CBFB, SMARCE1, PAX5, BACH2, MAF, BCLAF1, ESR1, OCA2, TP73, CTCF, TCF12, EP300, LMO1, SOX5, DPF2, PAX8, IRF4, SOX6, TEAD4, FOXA3, GATAD2A, EHMT2, MLX, EED, RBPJ, POU2F2, CDK7, ID3, CTBP1, MTA2, SRF, ARID3A, HNF4G, ERG, ZNF341, NFKB2, MYC, SMARCA4, ZKSCAN2, ARID1B, RAD21, HOMEZ, GRHL3, PROX1, RXRA, BATF3, GABPA, STAT3, XRCC5, ZNF614, IKZF1, RCOR1, MIER3, TERF2, ARNTL, NR3C1, HNRNPL, STAT5B, KMT2A, CREB1, SPI1, MIXL1, GATA2, ZNF644, DRAP1, RELB, NFIL3, ATF1, ETV5, RUNX1, SMC1A, BCL6, HDAC1, LDB1, CEBPA, SOX13, ZFX, AFF4, MEF2A, ZBTB2, ZNF384, NOTCH1, RUNX2, GATA4, ARNT, ZNF48, ATF2, SMAD4, HMBOX1, CBFA2T3, ETV6, FOXM1, SUPT5H, MED1, ZEB1, TEAD3, CEBPD, MYB, TERF1, PML, L3MBTL2, STAT5A, BCL11A, SP1, NIPBL, HNF4A, IKZF5, REST, ASH2L, BCOR, TCF3, SMC3, NCOR2, MLLT1, NFATC3, ZNF283, CBFA2T2, MEF2B, CBX3, FOXA2, EBF1, MTA3, CREM, NFATC1, MIER2, GTF2B, ZBED1, FOXF1, MEF2C, ZNF823, TCF7, CDK9, ZNF580, BCL3, KDM1A, YY1, RELA, JUNB, TCF4, SKIL, HIF1A, ZFP36, GATA3, BATF, TAL1, MAX, SPIB, GATA1, BCL11B, NR2F1, TP53, PKNOX1, NFKB1, ELF3, KAT8, TBX21, ARID4B, BHLHE40, AR, ZBTB26, NCOR1, RNF2, JUND, ILF3, BRD4, IKZF2, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 6
- Number of somatic mutations (non-coding): 0
- Related genes and loops