- Basic information
- CohesinDB ID: CDBP00417925
- Locus: chr21-34982607-34985119
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Data sourse: ENCSR000BSB, ENCSR000BLY, GSE103477, GSE111537, GSE131606, GSE165895, ENCSR000EFJ, GSE101921, ENCSR806UKK, GSE135093, GSE120943, GSE206145-NatGen2015, GSE138105, GSE116344, GSE98367, ENCSR193NSH, ENCSR879KXD, GSE206145, ENCSR000BMY, GSE129526, ENCSR000HPG, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE50893, GSE126755, ENCSR000ECS
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Cell type: MDM, RH4, SLK, OCI-AML-3, HuCC-T1, RPE, Fibroblast, HeLa-S3, GM2255, IMR-90, K-562, HFFc6, DKO, SNYDER, Monocytes, GM12878, GM12891, SK-N-SH, THP-1, Macrophage, GM12892, HCT-116, HEK293T, A-549, HCAEC, Neutrophil
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 16% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.711
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 33%,
"15_Quies": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, HMG20A, ZNF660, SOX2, MEIS2, XBP1, HNF1A, FOXA1, LEO1, PBX2, ZFHX2, TFAP4, HDGF, ATF3, NFIC, ZFP64, CHD7, PRDM1, RUNX3, ZNF189, SMARCE1, ZNF736, BACH2, CDX2, MAF, ZNF629, JMJD1C, TEAD1, TRIM28, KLF6, ETV1, NFE2L2, LMO2, ESR1, HNF1B, MLL, JUN, TCF12, CTCF, EP300, BAF155, ZBTB20, LMO1, SOX5, GATA6, DPF2, TRIM24, SOX6, E2F1, SMC1, TEAD4, KMT2B, ZNF175, GATAD2A, EHMT2, TFAP2C, EED, PDX1, POU2F2, MYCN, CDK7, RUNX1T1, MTA2, ZBTB48, ZSCAN5A, STAT1, SRF, HIC1, ARID3A, ERG2, ZNF300, ERG, HOXC5, ZBTB21, SMARCC2, ETS1, MYC, ZNF341, SMARCA4, NFKB2, ARID1B, HOMEZ, RAD21, LHX2, PHF21A, PROX1, RXRA, NKX2-1, BATF3, GABPA, STAT3, APC, XRCC5, ZNF398, IKZF1, RCOR1, NFE2, NR2F6, ZNF639, VDR, NFRKB, NR3C1, CEBPB, STAT5B, KMT2A, KLF8, GRHL2, ZHX2, SPI1, IRF1, HDAC2, GATA2, INTS13, FLI1, NR2C2, MRTFB, ZNF554, RUNX1, SMC1A, ZBTB24, CEBPA, HDAC1, MAFG, BCL6, SOX13, ZFX, SMAD3, ERG3, SMARCC1, PRDM10, RARA, ZNF35, NOTCH1, CREBBP, RUNX2, GATA4, OSR2, ZNF184, PBX4, NRF1, DAXX, ATF2, HMGB2, HMBOX1, ZNF518A, ZEB2, PBX3, FOXM1, ETV6, FOS, CDK8, PRDM9, MED1, GMEB1, ZXDB, MYB, C11orf30, L3MBTL2, EVI1, NUP98-HOXA9, MAFK, SP1, BCL11A, USF1, NR4A1, ARID2, REST, ZBTB7A, ATF7, PHIP, PRDM6, SMC3, MLLT1, ZNF394, NFATC3, SKI, MEF2B, CBX3, FOXA2, EBF1, CREM, SS18, NFATC1, ZNF692, GTF2B, WT1, MAFF, FOXF1, ZNF662, ZBTB33, MEF2C, CDK9, HOXB13, ZNF589, YY1, RELA, KDM1A, JUNB, ZNF148, AHR, TCF4, ZFP36, OTX2, GATA3, BATF, TAL1, MAX, SPIB, GATA1, MTA1, KLF4, ZNF592, SP7, GFI1B, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, PKNOX1, ZNF334, BCL6B, MYOD1, EGR2, NFKB1, BRD2, ELF3, TBX21, BHLHE40, AR, TAF1, RXR, ZNF324, ZNF366, EGR1, HSF1, RNF2, JUND, ILF3, SCRT1, BRD4, CUX1, MAZ, ZNF24, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 14
- Number of somatic mutations (non-coding): 0
- Related genes and loops