- Basic information
- CohesinDB ID: CDBP00417927
- Locus: chr21-34990740-34994113
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Data sourse: ENCSR000EFJ, GSE67783, GSE72082, GSE86191, GSE138405, GSE98367, GSE110061, ENCSR000HPG, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, GSE120943, ENCSR153HNT, GSE103477, GSE165895
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Cell type: MDM, RPE, Hela-Kyoto, Fibroblast, HCT-116, Hep-G2, Monocytes, RT-112, IMR-90, K-562, HSPC, Macrophage, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.856
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 30%,
"15_Quies": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, ZNF195, HMG20A, SOX2, MEIS2, ZNF621, HNF1A, XBP1, NME2, FOXA1, SUZ12, RBFOX2, LEO1, PBX2, MLL4, SMAD1-5, RXRB, HDGF, ATF3, NFIC, BMI1, CTCFL, RUNX3, CHD7, ZBTB5, CBFB, MECOM, SMARCE1, PAX5, TP63, ZSCAN4, MITF, ZNF736, BACH2, CDX2, CDC5L, MYOG, MAF, KLF5, JMJD1C, BCLAF1, TEAD1, KLF6, ETV1, NFE2L2, ELF1, RCOR2, ESR1, HNF1B, OCA2, TP73, ZNF217, HDAC8, USF2, ZIK1, CTCF, JUN, TCF12, EP300, E4F1, SOX5, DPF2, E2F6, TRIM24, RFX5, IRF4, SOX6, E2F4, ZNF398, ZNF410, ZNF776, E2F1, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, PDX1, TFAP2C, EED, RBPJ, EHMT2, POU2F2, NANOG, BRD1, ZSCAN5D, POU5F1, MYCN, TOP2A, ID3, ZNF263, CTBP1, MTA2, BRD3, DUX4, ZSCAN5A, STAT1, ZBTB48, THRAP3, SRF, GATAD1, DDX5, NBN, SAP130, ARID3A, PHB2, TBP, ZNF300, ERG, PBX1, ZNF597, ZNF341, NFKB2, MYC, TRIP13, SMARCA4, RFX1, HOMEZ, RAD21, LHX2, ARID1B, PROX1, RXRA, BATF3, GABPA, APC, XRCC5, STAT3, ZNF614, PRDM14, IKZF1, RCOR1, NFE2, NR2F6, MIER3, ARNTL, VDR, NR3C1, CEBPB, ZNF639, ESRRA, STAT5B, KMT2A, CREB1, CCAR2, YBX3, EZH2, TBL1XR1, CHD8, ARHGAP35, GRHL2, ZHX2, SPI1, IRF1, HDAC2, GATA2, ZNF644, SIX2, ZGPAT, SMARCA5, RELB, NFIL3, MYF5, ATF1, ETV5, PTBP1, RUNX1, THAP11, SMC1A, BCL6, CEBPA, HDAC1, EZH2phosphoT487, MAFG, SOX13, ZFX, AFF4, ZNF707, SMAD3, TET2, ERG3, ZNF473, NFXL1, ZNF513, TRIM22, SMARCC1, NSD2, MEF2A, RARA, ZNF384, NOTCH1, ZBTB2, BRD9, RUNX2, GATA4, OSR2, ZNF184, NRF1, ARNT, BACH1, ATF2, SMAD4, HMBOX1, ZEB2, PBX3, FOXM1, ETV6, FOS, CDK8, CBFA2T3, SNRNP70, SUPT5H, MED1, NR2C1, GMEB1, ZEB1, TEAD3, PML, MYB, SCRT2, TERF1, ZNF264, ZNF3, C11orf30, L3MBTL2, STAT5A, MAFK, BCL11A, SP1, NIPBL, HNF4A, PHF20, ARID2, REST, ZNF479, ATF7, ASH2L, HOXA9, PHIP, TCF3, FOXP1, BCOR, AFF1, AATF, SMC3, MLLT1, STAG1, ZNF239, NFATC3, SKI, TRP47, MEF2B, ZNF316, ZNF207, FOXA2, EBF1, MEIS1, SS18, MTA3, CREM, CBX3, ZBED1, GTF2B, WT1, ESR2, NFATC1, MAFF, ZNF662, MEF2C, TCF7, ZBTB33, CDK9, ZKSCAN1, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, ZNF148, ZNF521, MCM3, SP140, ZFP36, HIF1A, SKIL, ZIC2, GATA3, ZNF311, BATF, MGA, TAL1, MAX, ZNF143, MTA1, GATA1, PLAG1, KLF4, ZNF592, CEBPG, GFI1B, NR2F2, ZNF544, NR2F1, TCF7L2, KDM5B, TP53, PKNOX1, ZNF687, MED, NFKB1, MYOD1, BCL6B, BRD2, ELF3, KAT8, T, TBX21, ARID4B, BHLHE40, AR, ZBTB40, EGR1, HEXIM1, ZBTB26, RNF2, IKZF2, BRD4, JUND, NCOR1, SCRT1, HSF1, MAZ, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1
- Function elements
- Human SNPs: Mean_spheric_corpuscular_volume
- Number of somatic mutations (coding): 50
- Number of somatic mutations (non-coding): 0
- Related genes and loops