Deatailed information for cohesin site CDBP00417929

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  • Basic information
  • CohesinDB ID: CDBP00417929
  • Locus: chr21-34996052-35001042
  • Data sourse: GSE72082, GSE105028, GSE73207, GSE103477, GSE165895, ENCSR000EFJ, GSE67783, ENCSR000BKV, GSE86191, GSE206145-NatGen2015, GSE120943, GSE116344, GSE98367, ENCSR879KXD, GSE206145, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126755, GSE38411
  • Cell type: MDM, RH4, HuCC-T1, H9-hESC, RPE, Fibroblast, IMR-90, K-562, BCBL-1, HFFc6, Monocytes, TF-1, RT-112, THP-1, Macrophage, HCT-116, Hep-G2, Neutrophil, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 11% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.789
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 87% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 36%, "5_TxWk": 24%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, MEIS2, XBP1, FOXA1, RBFOX2, LEO1, PBX2, UBTF, HDGF, LYL1, ATF3, NFIC, RUNX3, ATF4, SMARCE1, MITF, CDC5L, MAF, JMJD1C, ZNF506, TEAD1, ELF1, TRIM28, NFE2L2, LMO2, ESR1, HDAC8, JUN, CTCF, TCF12, EP300, KLF1, E4F1, MNT, GATA6, DPF2, E2F6, TRIM24, SOX6, E2F4, ZNF528, TEAD4, GATAD2A, EHMT2, POU2F2, MYCN, ZNF263, RUNX1T1, ID3, CTBP1, MTA2, ASH1L, ZBTB48, STAT1, DDX5, NBN, ERG2, ARID3A, TBP, ERG, SMARCC2, ETS1, MYC, EZH1, SMARCA4, ARID1B, RAD21, FOXP2, GRHL3, FOXK2, BATF3, GABPA, PRDM14, IKZF1, LEF1, RCOR1, NR2F6, NFRKB, VDR, ZNF639, NR3C1, CEBPB, ESRRA, NFE2, STAT5B, ZNF750, KMT2A, EZH2, TBL1XR1, GABPB1, ZHX2, SPI1, IRF1, HDAC2, GATA2, FLI1, ZNF777, NR2C2, SMARCA5, ATF1, PTBP1, RUNX1, SMC1A, MAFG, HDAC1, BCL6, CEBPA, LDB1, ZFX, SMAD3, ERG3, ZBTB2, ZNF384, CREBBP, RARA, NOTCH1, BRD9, RUNX2, GATA4, ZNF184, ARNT, TFDP1, ZEB2, CBFA2T3, NR2C1, CDK8, MED1, GMEB1, TEAD3, DIDO1, CEBPD, MYB, ZNF3, NCOA1, L3MBTL2, C11orf30, EVI1, MAFK, BCL11A, NR4A1, REST, ZBTB7A, ATF7, POU2F3, AFF1, BCOR, TCF3, MLLT1, STAG1, NCOA4, CBFA2T2, ZNF316, CBX3, MTA3, FOXA2, PPARG, CREM, MEIS1, WT1, MAFF, ZBTB33, TCF7, MEF2C, CDK9, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, CREB3L1, TARDBP, NEUROD1, ZNF148, JUNB, SP140, HIF1A, GATA3, MGA, TAL1, MAX, SPIB, GATA1, MTA1, ZNF143, CEBPG, ZNF592, GFI1B, NR2F2, NCOA3, NR2F1, TCF7L2, NEUROG2, TP53, PKNOX1, MYOD1, EGR2, ARRB1, BHLHE40, AR, TAF1, ZBTB40, RXR, ZBTB42, EGR1, HSF1, NCOR1, RNF2, BRD4, JUND, ILF3, NOTCH3, MAZ, IRF9, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1
  • Function elements
  • Human SNPs: Plateletcrit
  • Number of somatic mutations (coding): 58
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000205670, ENSG00000159216,
  • Related loop: chr21:34350000-34375000~~chr21:34975000-35000000, chr21:34350000-34375000~~chr21:35000000-35025000, chr21:34750000-34775000~~chr21:35000000-35025000, chr21:34775000-34800000~~chr21:34975000-35000000, chr21:34775000-34800000~~chr21:35000000-35025000, chr21:34875000-34900000~~chr21:34975000-35000000, chr21:34875000-34900000~~chr21:35000000-35025000, chr21:34975000-35000000~~chr21:35825000-35850000, chr21:35000000-35025000~~chr21:35100000-35125000, chr21:35000000-35025000~~chr21:35825000-35850000,
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