- Basic information
- CohesinDB ID: CDBP00417930
- Locus: chr21-35002028-35002756
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Data sourse: ENCSR000BLD, GSE104888, GSE72082, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE105028, GSE121355, GSE25021, GSE108869, ENCSR000EDW, ENCSR000EFJ, GSE93080, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, GSE97394, ENCSR167MTG, GSE110061, GSE129526, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE50893, GSE126755
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Cell type: GM10847, GM2610, GM19240, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, GM12890, HeLa-S3, IMR-90, K-562, GM18486, GM18526, H1-hESC, SNYDER, GM18505, GM12878, GM19239, GM19193, GM19099, HUES64, GM12892, Hela-Kyoto, HCT-116, Hep-G2, GM19238, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 12% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.678
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 47%,
"5_TxWk": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: ZNF394, ZNF404, ZNF426, SMC1A, ZNF697, CBX3, TEAD4, GFI1B, ZNF433, ZNF101, ZFP37, SRF, ZNF654, LEO1, PBX2, ZNF580, PRDM10, ZNF529, YY1, ZNF19, ZBTB2, ZBTB21, NR2F2, AEBP2, ZBTB8A, ZNF341, ZNF266, ZNF510, ZFP64, RAD21, SP3, HIF1A, PRDM12, ZNF781, ZNF518A, ZNF189, MAX, ZNF10, GATA1, NFE2, ZNF639, ZNF629, TEAD3, ELF1, ZXDB, TRIM28, CREB1, ZNF680, ZNF560, SUPT16H, ZNF558, ZBTB11, PKNOX1, ZNF213, ZC3H11A, ZNF791, ZNF292, ZNF140, CTCF, ELF3, USF1, ZNF577, KLF1, BCL11A, ZNF664, ZNF202, REST, ZNF366, SMC1, ZNF623, SMC3, ZNF555, ZNF34, STAG1
- Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1
- Function elements
- Human SNPs: Balding_type_1
- Number of somatic mutations (coding): 6
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000159216,
- Related loop:
chr21:34350000-34375000~~chr21:34975000-35000000,
chr21:34350000-34375000~~chr21:35000000-35025000,
chr21:34750000-34775000~~chr21:35000000-35025000,
chr21:34775000-34800000~~chr21:34975000-35000000,
chr21:34775000-34800000~~chr21:35000000-35025000,
chr21:34875000-34900000~~chr21:34975000-35000000,
chr21:34875000-34900000~~chr21:35000000-35025000,
chr21:34975000-35000000~~chr21:35825000-35850000,
chr21:35000000-35025000~~chr21:35100000-35125000,
chr21:35000000-35025000~~chr21:35825000-35850000,