- Basic information
- CohesinDB ID: CDBP00417934
- Locus: chr21-35010595-35010671
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Data sourse: GSE120943, GSE98367
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Cell type: Monocytes, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 51%,
"5_TxWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, E2F7, NME2, XBP1, FOXA1, LEO1, MEN1, LYL1, ZNF90, ATF3, ATF4, SMARCE1, ZSCAN4, JMJD1C, ELF1, TRIM28, LMO2, ESR1, MLL, OCA2, JUN, TCF12, CTCF, BAF155, EP300, ARID5B, LMO1, DPF2, FOSL2, ZNF528, TEAD4, EHMT2, ZSCAN5D, POU5F1, MYCN, RUNX1T1, ID3, ZNF263, ZNF317, ZBTB48, ZSCAN5A, STAT1, DDX5, ARID3A, ERG, HOXC5, MYC, SMARCA4, ARID1B, RAD21, GRHL3, STAT3, IKZF1, RCOR1, VDR, NR3C1, CEBPB, STAT5B, KMT2A, ZHX2, SPI1, GATA2, ZNF644, ZNF880, FLI1, ATF1, RUNX1, ZNF585A, SMC1A, ZBTB24, HDAC1, LDB1, EZH2phosphoT487, CEBPA, ZFX, SMAD3, PCBP2, SMARCC1, ZBTB2, NOTCH1, RUNX2, GATA4, ARNT, PBX4, DAXX, PRDM9, CBFA2T3, FOS, CDK8, MED1, MYB, SCRT2, ZMYM3, SMAD1, ZNF3, C11orf30, EVI1, KLF16, BCL11A, REST, ZBTB7A, ATF7, TCF3, FOXP1, BCOR, SMC3, MLLT1, STAG1, SKI, FOXA2, TBL1X, CREM, MEIS1, WT1, MAFF, FOXF1, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, ZFP36, TCF4, GATA3, TAL1, MAX, GATA1, ZNF143, KLF4, CEBPG, ZNF592, NCOA3, NR2F2, NR2F1, MYOD1, T, TBX21, BHLHE40, AR, PAX3-FOXO1, RNF2, BRD4, JUND, ILF3, CLOCK, SCRT1, MAZ, RUNX1-3
- Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 2
- Number of somatic mutations (non-coding): 0
- Related genes and loops