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Basic information

CohesinDB ID: CDBP00417940

Locus: chr21-35025268-35030343

Data sourse: ENCSR000BLD, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE73207, GSE103477, GSE111537, GSE131606, GSE25021, ENCSR000EDW, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE93080, ENCSR000DZP, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, GSE130135, GSE94872, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE62063, ENCSR000BMY, GSE97394, GSE55407, ENCSR167MTG, ENCSR000HPG, GSE111913, GSE155324, GSE38411, ENCSR054FKH, ENCSR153HNT, GSE50893, GSE126755, GSE131577

Cell type: MDM, GM10847, GM2610, GM19240, OCI-AML-3, HSPC, Liver, B-cell, H9-hESC, GM2630, RPE, Fibroblast, GM12890, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, TF-1, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, THP-1, GM19099, HUES64, Macrophage, GM12892, Ramos, HCT-116, HL-60, HEK293T, Hep-G2, HUVEC, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 28% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.456

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 22%, "2_TssAFlnk": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RELA, ZSCAN5D, TRIM28, SMARCA4, ZFX, NOTCH3, PRDM9, SMC3, LEO1, STAG1, TFAP2C

Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A,RCAN1,MORC3,SETD4,CLIC6

Function elements

Human SNPs: Eosinophil_percentage_of_granulocytes

Number of somatic mutations (coding): 40

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917, ENSG00000159256,

eachgene

Deatailed information for cohesin site CDBP00417940