Browse_each

Basic information

CohesinDB ID: CDBP00417943

Locus: chr21-35035550-35039035

Data sourse: GSE72082, GSE103477, GSE25021, ENCSR000EDW, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR167MTG, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE131577

Cell type: MCF-7, MDM, RPE, Hela-Kyoto, Fibroblast, HCT-116, HEK293T, Hep-G2, HL-60, Monocytes, HeLa-S3, K-562, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 8% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.844

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 24%, "7_Enh": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: HMG20A, SOX2, MEIS2, NME2, XBP1, FOXA1, LEO1, PBX2, ZNF596, HDGF, RUNX3, ZSCAN4, MITF, MAF, NFE2L2, ESR1, USF2, CTCF, TCF12, BAF155, SOX5, DPF2, PAX8, RAD51, FOXA3, TFAP2C, EED, POU2F2, CHD8, ZSCAN5D, MYCN, ZNF263, RUNX1T1, ZBTB48, ZSCAN5A, STAT1, SAP130, ERG, MYC, EZH1, SMARCA4, RAD21, GRHL3, NKX2-1, GABPA, STAT3, XRCC5, PRDM14, IKZF1, NFE2, SRSF3, STAT5B, KMT2A, CREB1, EZH2, SPI1, HDAC2, FLI1, NFIL3, RUNX1, MAFG, CBX1, SMC1A, SIN3A, ZFX, SOX13, ZNF770, ERG3, ZBTB2, RUNX2, ARNT, PRDM9, TEAD3, MYB, ZMYM3, ZNF3, C11orf30, USF1, BCL11A, NR4A1, REST, RBM25, BCOR, FOXP1, SMC3, MLLT1, STAG1, CBFA2T2, FOXA2, TBL1X, WT1, HOXB13, YY1, NEUROD1, SP140, ZFP36, OTX2, TAL1, MAX, SPIB, ZNF143, GATA1, TLE3, BCL11B, PKNOX1, ZNF334, MYOD1, ELF3, TBX21, AR, NCOR1, NOTCH3, BRD4, MAZ, ZNF316

Target gene symbol (double-evidenced CRMs): MORC3,RUNX1,CLIC6,RCAN1,SETD4,SMIM11A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 380

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917, ENSG00000159256,

eachgene

Deatailed information for cohesin site CDBP00417943