Browse_each

Basic information

CohesinDB ID: CDBP00417944

Locus: chr21-35039690-35041679

Data sourse: GSE126755, ENCSR167MTG, ENCSR000EEG, ENCSR338DUC, ENCSR230ZWH, ENCSR000BKV, GSE72082, GSE98367, ENCSR000BLS, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, GSE62063, GSE120943, ENCSR153HNT, GSE103477, GSE25021, GSE50893, ENCSR000EDW, GSE165895

Cell type: MCF-7, GM12892, MDM, Fibroblast, RPE, Monocytes, Hep-G2, SNYDER, Ramos, GM12891, K-562, Liver, Neutrophil, Macrophage, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 9% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 22%, "15_Quies": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, KDM3A, HDGF, MEN1, THAP1, ZBTB44, PAX5, TEAD1, LMO2, OCA2, PITX3, HDAC8, ZNF577, ARID5B, E4F1, SOX5, PAX8, DEK, E2F4, ZNF410, ZNF528, ZNF555, KMT2B, GATAD2A, NANOG, ZNF263, BRD3, TOP2A, POU5F1, CTBP1, DUX4, STAT1, SAP130, ERG, ZBTB21, PAX6, ZNF597, NFKB2, EZH1, SMARCA4, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, CD74, NFRKB, CEBPB, CREB1, GABPB1, ZHX2, ELF4, MIXL1, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, CRY1, REPIN1, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ATF2, FOXM1, SMARCB1, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, IKZF5, ARID2, OVOL3, RBM25, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, NFATC1, SS18, PAF1, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, ZNF510, TCF4, ZFP36, BATF, SPIB, PLAG1, ZFP69B, BCL11B, KLF4, ZNF544, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, RUNX1-3, FOSL1, ZNF660, HNF1A, XBP1, ZNF101, KDM4B, PBX2, ZNF596, ATF3, ZC3H8, THRB, ZFP64, RUNX3, CBFB, DPF1, ZSCAN4, TP63, MITF, BACH2, ZNF467, JMJD1C, MYOG, MAF, ELF1, INTS11, ZNF573, RBM39, SNAI2, SMAD5, CTCF, JUN, LMO1, ZBTB20, MNT, DPF2, RYBP, IRF4, ZNF350, PDX1, RBPJ, TFAP2C, MLX, ZNF239, MTA2, ZBTB17, ZBTB48, ZSCAN21, SRF, DDX5, NBN, CHD4, PBX1, ONECUT1, ZNF2, HOMEZ, TSHZ1, LHX2, FOXP2, RXRA, BATF3, NKX3-1, PRDM14, MIER3, TERF2, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, TBL1XR1, KLF8, SSRP1, ZNF146, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, ZBTB24, EZH2phosphoT487, SOX13, AFF4, ZNF18, DAXX, ARNT, BACH1, ZNF48, PRDM9, HMBOX1, ZEB2, NFYA, ETV6, PBX3, ZNF10, HMGXB4, ICE2, TEAD3, ZXDB, KLF9, USF1, SP1, BCL11A, ATF7, ASH2L, PRDM6, ZNF623, SMC3, STAG1, MLLT1, STAG2, ZNF394, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, ZNF155, GATA3, TAL1, NRIP1, ZNF143, MTA1, CBX2, TP53, ZNF334, NFKB1, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, RNF2, IKZF2, BRD4, JUND, ZSCAN23, SMAD4.1D12, IRF9, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, TFAP4, BMI1, CHD7, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, ZNF260, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, KDM4C, ZSCAN5A, HIC1, ERG2, TBP, HNF4G, HOXC5, SMARCC2, ETS1, MYC, ARID1B, ZNF24, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, EZH2, ZNF652, PHF8, SPI1, HDAC2, INTS13, GATAD2B, ZNF76, NFYB, NCOA2, ETV5, BCL6, SIN3A, ZFP37, ERG3, MEF2A, RARA, ZNF384, CREBBP, ZNF35, HMGB2, ZNF518A, SMAD4, CBFA2T3, CDK8, ZEB1, SPDEF, ZMYM3, SUPT16H, NCOA1, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ZNF34, PPARG, TBL1X, ZNF692, GTF2B, JDP2, ZNF662, TCF7, ZNF823, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, TCF7L2, NEUROG2, KDM5B, ZNF791, NR2F1, PKNOX1, MYOD1, AR, PAX3-FOXO1, ZNF324, ZNF280D, DMAP1, FOSL2, AHR, ZNF391, HMG20A, ZSCAN5C, MEIS2, SUZ12, RBFOX2, ZFHX2, LYL1, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, HNF1B, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, SOX6, CREB3, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, ID3, RUNX1T1, MLLT3, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, JMJD6, FEZF1, TFE3, EHF, ZSCAN2, IRF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, SMC1A, MAFG, CBX1, ZNF335, ZFX, FIP1L1, SMAD3, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, NRF1, NR2C1, SUPT5H, CHD1, FOS, MED1, CEBPD, MYB, SCRT2, ZNF558, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, ZNF283, KLF13, FOXA2, RBBP5, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, SP140, HIF1A, BHLHE22, OTX2, ZNF449, GATA1, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF843, NFKBIZ, BHLHE40, TAF1, ZBTB40, MYNN, NOTCH3, CLOCK, MAZ, MEF2D, BRCA1

Target gene symbol (double-evidenced CRMs): MORC3,RUNX1,SMIM11A,RCAN1,CLIC6,SETD4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 20

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917, ENSG00000159256,

eachgene

Deatailed information for cohesin site CDBP00417944