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Basic information

CohesinDB ID: CDBP00417945

Locus: chr21-35042107-35054875

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE73207, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CUTLL1, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, T-47D, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 81% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.144

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,Intragenic,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 29%, "2_TssAFlnk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, HMG20A, SOX2, MEIS2, FOXA1, HLF, RBFOX2, RXRB, PBX2, KDM3A, ZFP64, CHD7, MXD4, KLF5, TEAD1, KLF6, RCOR2, ESR1, OCA2, USF2, CTCF, MNT, SOX5, SOX4, E2F6, FOXA3, ZNF175, GATAD2A, PDX1, RBPJ, MLX, CDK9-HEXIM1, ZSCAN5D, ZNF263, MYCN, POU5F1, ZBTB48, GATAD1, SAP130, OGG1, MYC, SMARCA4, RAD21, GRHL3, STAT3, XRCC5, ZNF614, IKZF1, RCOR1, MIER3, NR2F6, DNMT3B, NR3C1, CREB1, GRHL2, ZNF652, GABPB1, SPI1, MIXL1, TFE3, ZNF257, HDAC2, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, ZGPAT, NFIL3, RUNX1, THAP11, BCL6, SMC1A, CEBPA, SOX13, ZFX, ZXDC, RARA, NFYC, RUNX2, ZNF48, SMAD4, MAFB, HMGXB4, TGIF2, TEAD3, DIDO1, ZEB1, ZNF3, L3MBTL2, MBD1, USF1, GSPT2, NR4A1, IKZF5, REST, POU2F3, CTBP2, PHIP, TCF3, FOXP1, AATF, SMC3, STAG1, TRP47, CBFA2T2, CBX3, FOXA2, MIER2, MAFF, WT1, FOXF1, ZBTB33, MEF2C, ZNF580, YY1, AHR, SP140, MGA, MAF1, MAX, HAND2, PLAG1, CEBPG, ZNF592, NR2F2, NEUROG2, ELF3, BRD2, KAT8, NFKBIZ, ARID4B, BHLHE40, AR, ZBTB26, HSF1, NOTCH3, BRD4, MAZ, DMAP1

Target gene symbol (double-evidenced CRMs): SETD4,CLIC6,MORC3,RCAN1,SMIM11A,RUNX1

Function elements

Human SNPs: Mean_corpuscular_hemoglobin

Number of somatic mutations (coding): 245

Number of somatic mutations (non-coding): 39

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917, ENSG00000159256,

eachgene

Deatailed information for cohesin site CDBP00417945