- Basic information
- CohesinDB ID: CDBP00417981
- Locus: chr21-35135842-35140867
-
Data sourse: ENCSR000BLD, GSE104888, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE121355, GSE131606, GSE108869, GSE165895, ENCSR000EFJ, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE101921, GSE135093, GSE51234, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, ENCSR895JMI, GSE130140, GSE206145, GSE85526, ENCSR000ECE, ENCSR000BMY, ENCSR000BTQ, GSE105004, GSE131956, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS
-
Cell type: RH4, SLK, GM19240, CUTLL1, GP5d, HuCC-T1, B-cell, RPE, GM2630, HMEC, Fibroblast, HEKn, GM12890, HeLa-S3, IMR-90, K-562, GM18486, DKO, HFFc6, H1-hESC, SNYDER, GM18505, GM12878, GM12891, GBM39, SK-N-SH, GM19239, RT-112, MCF-7, GM12892, Hela-Kyoto, HCT-116, MCF-10A, Hep-G2, A-549, HCAEC, HeLa, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 24% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.578
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 44%,
"7_Enh": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, CBX5, HMG20A, SOX2, XBP1, FOXA1, RXRB, PBX2, MLL4, SMAD1-5, ZFHX2, TFAP4, HDGF, ATF3, THRB, NFIC, CHD7, RUNX3, SMARCE1, TP63, BACH2, CDX2, MYOG, MAF, KLF5, TEAD1, ELF1, TRIM28, KLF6, ETV1, NFE2L2, SNAI2, RCOR2, ESR1, OCA2, MED26, HNF1B, RBM39, TP73, USF2, LMO2, CTCF, JUN, TCF12, EP300, ARID5B, E4F1, LMO1, GATA6, DPF2, E2F6, TRIM24, SOX6, E2F1, SMC1, TEAD4, PDX1, TFAP2C, RBPJ, POU2F2, MYCN, POU5F1, TOP2A, ID3, KDM4C, CTBP1, CDK7, RUNX1T1, ZBTB48, ZSCAN5A, STAT1, ERG2, TBP, ERG, HOXC5, PAX6, SMARCC2, ETS1, MYC, SMARCA4, ARID1B, RAD21, HOMEZ, GRHL3, PROX1, RXRA, FOXK2, NKX2-1, GABPA, APC, STAT3, XRCC5, IKZF1, RCOR1, NFE2, NR2F6, DACH1, ARNTL, VDR, NR3C1, ESRRA, ZNF750, CEBPB, KMT2A, EZH2, GRHL2, ZHX2, SPI1, IRF1, HDAC2, GATA2, ZNF644, FLI1, SMARCA5, NCOA2, MYF5, ATF1, ETV5, ZNF316, RUNX1, BCL6, SMC1A, HDAC1, EZH2phosphoT487, CEBPA, AFF4, ZFX, SOX13, SIN3A, ZNF534, SMAD3, ERG3, SMARCC1, CREBBP, RARA, ZBTB2, NOTCH1, RUNX2, JMJD1C, GATA4, PBX4, DAXX, NRF1, ARNT, ZEB2, SMAD4, ZNF518A, CBFA2T3, PBX3, FOXM1, SMARCB1, CDK8, FOS, MED1, GMEB1, ZEB1, TEAD3, MYB, ZNF680, ZNF3, KLF9, STAT5A, MAFK, NIPBL, SP1, USF1, HNF4A, BCL11A, REST, ZBTB7A, PHIP, MBD2, BCOR, TCF3, SMC3, ELL2, ZNF34, STAG1, STAG2, MLLT1, ZNF283, CBFA2T2, MEF2B, PPARG, FOXA2, TBL1X, CBX3, CHD2, PAF1, EBF1, SS18, CREM, GTF2B, WT1, NFATC1, KDM1A, YY1, RELA, JUNB, NEUROD1, SP140, ZFP36, HIF1A, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, MTA1, GATA1, KLF4, ZNF592, BCL11B, GFI1B, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, SMAD1-5-8, MYOD1, BRD2, ELF3, BCLAF1, BHLHE40, AR, PAX3-FOXO1, TAF1, YAP1, EGR1, ZBTB26, NCOR1, RNF2, BRD4, JUND, MAZ, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 20
- Related genes and loops