- Basic information
- CohesinDB ID: CDBP00417985
- Locus: chr21-35147338-35147884
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Data sourse: GSE206145, GSE101921, GSE85526, GSE68388
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Cell type: RPE, HMEC, HuCC-T1, HEKn
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: Mau2,NIPBL,SA2,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 78%,
"14_ReprPCWk": 9%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, POU2F2, SMC1A, PGR, POU5F1, SOX2, SMAD3, ESR2, FOXA1, HOXC5, ERG, RELA, GATA4, PBX4, OTX2, ATF2, STAT3, FOXM1, TP63, FOS, CDK8, KLF4, NR3C1, KLF5, TEAD1, KLF6, TP53, HNF1B, ESR1, JUN, BRD2, ELF3, SPI1, AR, IRF1, YAP1, FLI1, HSF1, BRD4, PHIP, E2F1, TEAD4, FOSL2
- Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000159216,
- Related loop:
chr21:34350000-34375000~~chr21:35125000-35150000,
chr21:34350000-34375000~~chr21:35150000-35175000,
chr21:34850000-34875000~~chr21:35150000-35175000,
chr21:34875000-34900000~~chr21:35125000-35150000,
chr21:34875000-34900000~~chr21:35150000-35175000,
chr21:35050000-35075000~~chr21:35150000-35175000,
chr21:35125000-35150000~~chr21:35250000-35275000,
chr21:35125000-35150000~~chr21:35375000-35400000,
chr21:35125000-35150000~~chr21:35825000-35850000,