- Basic information
- CohesinDB ID: CDBP00417998
- Locus: chr21-35178366-35181009
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Data sourse: ENCSR000EFJ, GSE138405, ENCSR000HPG, ENCSR000BLY, GSE206145, GSE101921, GSE135093, GSE85526, GSE206145-NatGen2015, ENCSR000EDE, GSE68388, GSE83726, GSE116344, GSE126990, GSE108869, GSE165895
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Cell type: RPE, HMEC, Hela-Kyoto, Fibroblast, RH4, HEKn, HeLa-S3, IMR-90, SK-N-SH, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 8% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.878
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 68%,
"7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, E2F7, XBP1, FOXA1, SUZ12, ATF3, NFIC, RUNX3, CHD7, MITF, BACH2, MYOG, MAF, TEAD1, KLF6, SNAI2, NFE2L2, ESR1, OCA2, JUN, TCF12, CTCF, EP300, TRIM24, IRF4, RAD51, E2F1, TEAD4, EED, MYCN, ID3, HOXC5, ETS1, MYC, RAD21, GRHL3, RXRA, BATF3, STAT3, APC, RCOR1, ARNTL, NR3C1, CEBPB, ZNF750, CREB1, EZH2, GRHL2, SPI1, IRF1, GATA2, MYF5, SMC1A, AFF4, ZFX, POU4F2, SMAD3, PRDM10, CREBBP, RUNX2, ARNT, PBX4, SOX11, DAXX, PBX3, ETV6, FOS, CDK8, MED1, MAFK, BCL11A, NR4A1, TCF3, STAG2, PPARG, MTA3, EBF1, NFATC1, ZNF30, ESR2, BCL3, RELA, JUNB, HIF1A, GATA3, BATF, MAX, ZNF143, KLF4, NCOA3, KDM5B, TP53, NFKB1, MYOD1, BRD2, BHLHE40, AR, PAX3-FOXO1, NOTCH3, BRD4, JUND, FOSL2
- Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops