- Basic information
- CohesinDB ID: CDBP00417999
- Locus: chr21-35188735-35190902
-
Data sourse: GSE104888, ENCSR230ZWH, ENCSR000BSB, ENCSR000BLY, GSE131606, GSE108869, GSE165895, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE138405, GSE101921, GSE206145-NatGen2015, GSE116344, ENCSR895JMI, ENCSR000EHW, GSE206145, GSE62063, ENCSR000BMY, ENCSR000EHX, GSE38395, GSE129526, GSE111913, GSE155324, ENCSR000EDE, GSE68388, GSE126990, GSE50893, ENCSR000ECS
-
Cell type: RH4, Liver, HuCC-T1, B-cell, RPE, HMEC, Fibroblast, GM12890, HeLa-S3, hLCL, GM2255, HFFc6, SNYDER, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, Ramos, GM12892, Hela-Kyoto, HCT-116, A-549, GM19238
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 14% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.711
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 45%,
"7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, SOX2, FOXA1, TFAP4, ATF3, NFIC, CHD7, RUNX3, ZNF189, PAX5, TP63, MITF, BACH2, CDX2, TEAD1, BCLAF1, ETV1, KLF6, SNAI2, ZNF217, ESR1, PITX3, USF2, JUN, TCF12, EP300, IRF4, TRIM24, RAD51, TEAD4, RBPJ, EED, TFAP2C, GLIS1, POU2F2, MYCN, BRD3, MTA2, ZSCAN21, ZBTB48, DUX4, ERG, HOXC5, ONECUT1, MYC, SMARCA4, TSHZ1, RAD21, RXRA, PROX1, NKX2-1, GABPA, STAT3, IKZF1, RCOR1, TERF2, ZNF639, VDR, NR3C1, CEBPB, ZNF750, ESRRA, KMT2A, CREB1, KLF8, EBF3, SPI1, ZNF664, EHF, IRF1, GATA2, SIX2, FLI1, RELB, ZIM3, SMC1A, BCL6, ZBTB24, SIN3A, SMAD3, TWIST1, PRDM10, MEF2A, CREBBP, ZNF384, ZBTB2, RUNX2, GATA4, OSR2, ZNF184, PBX4, NRF1, DAXX, ATF2, ETV6, FOXM1, PBX3, FOS, CDK8, MED1, ZEB1, TERF1, PML, MYB, STAT5A, USF1, NIPBL, SP1, BCL11A, HNF4A, REST, PHIP, BCOR, FOXP1, TCF3, SMC3, ELL2, NCOR2, STAT2, STAG2, MEF2B, FOXA2, MTA3, EBF1, CHD2, CREM, CBX3, ZNF600, GTF2B, TCF7, CDK9, YY1, RELA, TARDBP, JUNB, SKIL, HIF1A, GATA3, BATF, MAX, SPIB, ZNF143, KLF4, SP7, NCOA3, NR2F2, TCF7L2, TP53, MYOD1, BRD2, ELF3, TBX21, AR, PAX3-FOXO1, TAF1, RXR, ZNF366, ZBTB42, NCOR1, IKZF2, JUND, BRD4, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1
- Function elements
- Human SNPs: Protein_quantitative_trait_loci_(liver)
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops