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Basic information

CohesinDB ID: CDBP00418003

Locus: chr21-35200950-35209885

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE25021, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE135093, GSE206145-NatGen2015, GSE120943, GSE138105, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE62063, ENCSR000BMY, GSE97394, GSE55407, ENCSR000BTQ, ENCSR167MTG, GSE131956, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, Liver, HuCC-T1, H9-hESC, B-cell, GM2630, RPE, Fibroblast, GM12890, IMR-90, K-562, GM18486, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, MB157, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, RT-112, THP-1, Macrophage, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, HUVEC, HCAEC, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 35% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.489

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 34%, "15_Quies": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: ARNTL, FOXA2, RBM25, ZSCAN29, ZMYM3, XBP1, GRHL3

Target gene symbol (double-evidenced CRMs): RUNX1,SETD4,SMIM11A,RCAN1

Function elements

Human SNPs: Heel_bone_mineral_density

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00418003