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Basic information

CohesinDB ID: CDBP00418004

Locus: chr21-35211918-35213403

Data sourse: ENCSR000EFJ, ENCSR000HPG, ENCSR879KXD, GSE206145, GSE206145-NatGen2015, GSE135093, GSE83726, GSE116344, GSE50893, GSE165895

Cell type: RPE, GM12892, GM2630, Fibroblast, RH4, SNYDER, GM19240, GM12878, GM12891, GM2588, GM12890, IMR-90, K-562, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 8% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.844

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 49%, "5_TxWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, MEF2B, PPARG, BCL6, HDAC1, EBF1, MYCN, ID3, FOXA2, SMAD3, FOXA1, PBX2, HOXB13, SMARCC1, HOXC5, MEF2A, RELA, ASCL1, JUNB, MYC, NFIC, SMARCA4, RUNX2, RAD21, RUNX3, TCF4, LHX2, GRHL3, BHLHE22, GATA3, ATF2, BATF, OTX2, STAT3, MAX, TAL1, SPIB, GATA1, IKZF1, FOS, MED1, VDR, NR3C1, CEBPB, MYOG, KLF4, STAT5B, TRIM28, KMT2A, ZEB1, NEUROG2, KLF6, SNAI2, ESR1, PKNOX1, TP53, MYOD1, CTCF, ELF3, JUN, SPI1, AR, IRF1, GATA2, IRF4, FOSL2, BRD4, E2F1, EED

Target gene symbol (double-evidenced CRMs): SETD4,RUNX1,SMIM11A,RCAN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159216, ENSG00000185917,

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Deatailed information for cohesin site CDBP00418004