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Basic information

CohesinDB ID: CDBP00418006

Locus: chr21-35216589-35221378

Data sourse: GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR150EFU, ENCSR000ECS, GSE121355, GSE131606, GSE108869, GSE25021, ENCSR000BUC, GSE165895, ENCSR000EFJ, GSE86191, GSE138405, GSE76893, GSE101921, GSE135093, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, ENCSR895JMI, ENCSR193NSH, ENCSR879KXD, GSE206145, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR853VWZ, ENCSR956LGB, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, ENCSR748MVX

Cell type: RH4, SLK, HuCC-T1, RPE, HMEC, Fibroblast, HEKn, HeLa-S3, IMR-90, K-562, HFFc6, DKO, MB157, RT-112, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, A-549, HeLa

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 27% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.778

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 43%, "5_TxWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, FOXO1, FOSL1, PGR, ZNF660, SOX2, XBP1, FOXA1, PBX2, TFAP4, MEN1, ATF3, ZC3H8, CHD7, ATF4, SMARCE1, TP63, MITF, CDX2, MAF, KLF5, TEAD1, ELF1, KLF6, SNAI2, ZNF217, ESR1, HNF1B, HDAC8, USF2, CTCF, JUN, TCF12, BAF155, EP300, MNT, GATA6, PYGO2, DPF2, IRF4, RFX5, TRIM24, SOX6, DEK, RAD51, DDX20, SMC1, TEAD4, ZNF175, EHMT2, TFAP2C, ID3, CTBP1, ZSCAN21, ZBTB17, STAT1, ZNF205, DDX5, ZNF300, ERG, HOXC5, PAX6, MYC, SMARCA4, ARID1B, RAD21, GRHL3, PROX1, NKX2-1, RXRA, GABPA, STAT3, APC, NKX3-1, RCOR1, ZNF639, ARNTL, NR3C1, ZNF750, CEBPB, ESRRA, CREB1, KLF8, GRHL2, FEZF1, TRPS1, ZHX2, EHF, IRF1, HDAC2, GATA2, GATAD2B, SIX2, NR2C2, SMARCA5, NCOA2, RUNX1, CBX1, SMC1A, MAFG, NKX2-2, AFF4, ZFX, SIN3A, SMAD3, SMARCC1, TWIST1, PRDM10, CREBBP, ZXDC, RUNX2, CDK6, GATA4, GR, ARNT, PBX4, DAXX, ATF2, ZEB2, FOXM1, PBX3, FOS, CDK8, MED1, ZNF584, ZEB1, MYB, SCRT2, PIAS1, NR1H2, C11orf30, L3MBTL2, NCOA1, ZNF41, MAFK, NIPBL, SP1, TFAP2A, HNF4A, ARID1A, ZHX1, ATF7, ASH2L, CTBP2, PHIP, MBD2, FOXP1, SMC3, ELL2, STAG1, STAG2, FOXA2, CBX3, CHD2, PAF1, MAFF, ESR2, CDK9, HOXB13, ZNF589, ZNF19, KDM1A, RELA, TARDBP, NEUROD1, AHR, JUNB, HIF1A, GATA3, MGA, MAX, NRIP1, ZNF143, MTA1, GATA1, KLF4, ZNF592, CEBPG, NCOA3, NR2F2, SP7, TCF7L2, NR2F1, KDM5B, TP53, ZNF687, PKNOX1, NFKB1, MYOD1, PHOX2B, ELF3, BRD2, T, BHLHE40, AR, ZNF579, ZBTB40, YAP1, EGLN2, RNF2, NOTCH3, BRD4, JUND, CLOCK, CUX1, ZNF24, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): SETD4,RCAN1,RUNX1,SMIM11A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00418006