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Basic information

CohesinDB ID: CDBP00418007

Locus: chr21-35221773-35224106

Data sourse: ENCSR230ZWH, GSE72082, GSE98367, GSE138405, GSE129526, GSE206145, GSE101921, GSE62063, GSE206145-NatGen2015, GSE68388, ENCSR703TNG, GSE50893, ENCSR917QNE

Cell type: GM2610, GM19240, Liver, HuCC-T1, B-cell, RPE, GM2630, Fibroblast, GM18486, GM18526, SNYDER, GM12891, GM2588, GM19239, GM19193, Macrophage, Ramos, MCF-7, GM12892, Hela-Kyoto, HCT-116, HCAEC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 8% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.756

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 33%, "15_Quies": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOXA1, PBX2, ZFHX2, NFIC, RUNX3, ZBTB44, BACH2, MAF, JMJD1C, TEAD1, TRIM28, ELF1, KLF6, BCLAF1, ESR1, HNF1B, CTCF, JUN, BAF155, MNT, TRIM24, IRF4, ZNF776, E2F1, SMC1, TEAD4, EHMT2, RBPJ, MYCN, RUNX1T1, ID3, TOP2A, STAT1, ARID3A, ERG2, HOXC5, ERG, PBX1, MIER1, ETS1, MYC, RAD21, RXRA, GABPA, APC, STAT3, IKZF1, NR2F6, VDR, ARNTL, ESRRA, CEBPB, STAT5B, KMT2A, CREB1, GRHL2, SPI1, HDAC2, FLI1, MXI1, NR2C2, RUNX1, SMC1A, BCL6, SIN3A, SMAD3, ERG3, PRDM10, ZBTB2, RARA, ZNF384, RUNX2, PBX4, HMGB2, ETV6, FOS, MED1, MYB, SCRT2, ZMYM3, USF1, BCL11A, SP1, NR4A1, HNF4A, REST, RBM25, PHIP, TCF3, BCOR, FOXP1, AFF1, MTA3, MIER2, ESR2, MEF2C, CDK9, HOXB13, KDM1A, RELA, ZFP36, HIF1A, GATA3, TAL1, MAX, SPIB, ZNF143, NRIP1, NR2F2, NR2F1, ZNF768, KDM5B, TP53, NFKB1, EGR2, ELF3, BRD2, AR, ZBTB40, EGLN2, NCOR1, BRD4, SCRT1, ZNF24, ZNF316

Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1,SETD4,RCAN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159216, ENSG00000185917,

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Deatailed information for cohesin site CDBP00418007