Deatailed information for cohesin site CDBP00418010

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  • Basic information
  • CohesinDB ID: CDBP00418010
  • Locus: chr21-35230893-35235351
  • Data sourse: GSE104888, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE121355, GSE111537, GSE131606, GSE108869, GSE25021, GSE165895, ENCSR000EFJ, GSE93080, GSE143937, GSE86191, GSE138405, GSE101921, GSE135093, GSE206145-NatGen2015, GSE120943, GSE138105, GSE130135, GSE116344, ENCSR703TNG, GSE94872, GSE98367, ENCSR879KXD, GSE206145, GSE62063, ENCSR000BTQ, GSE105004, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS
  • Cell type: RH4, SLK, GM19240, HuCC-T1, B-cell, RPE, HMEC, Fibroblast, GM12890, HeLa-S3, IMR-90, K-562, HFFc6, DKO, SNYDER, Monocytes, GM12878, GM12891, SK-N-SH, GM19239, RT-112, Macrophage, Ramos, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, HUVEC, HCAEC, HeLa, OCI-AML-3
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 21% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.644
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 84% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 43%, "7_Enh": 27%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, CBX5, HMG20A, ZNF660, SOX2, MEIS2, HNF1A, FOXA1, PBX2, UBTF, MLL4, TFAP4, HNRNPK, HDGF, ATF3, ZC3H8, NFIC, CHD7, RUNX3, CBFB, SMARCE1, TP63, ZSCAN4, MITF, CDX2, MAF, JMJD1C, TEAD1, BCLAF1, TRIM28, KLF6, ETV1, NFE2L2, ZNF217, ESR1, OCA2, HNF1B, MLL, TP73, USF2, CTCF, TCF12, JUN, EP300, ARID5B, MNT, LMO1, DPF2, SOX4, TRIM24, RFX5, IRF4, SOX6, E2F4, ZNF410, E2F1, ZNF528, SMC1, TEAD4, KMT2B, ZNF175, PDX1, TFAP2C, EHMT2, EED, RBPJ, POU2F2, ZSCAN5D, MYCN, BRD3, CDK7, CTBP1, MTA2, STAT1, SRF, TBP, HOXC5, PAX6, ERG, PBX1, SMARCC2, ETS1, MYC, SMARCA4, ARID1B, RAD21, LHX2, GRHL3, FOXP2, PROX1, NKX2-1, FOXK2, RXRA, GABPA, STAT3, APC, XRCC5, IKZF1, RCOR1, LEF1, NR2F6, DACH1, ARNTL, VDR, NR3C1, CEBPB, KMT2A, CREB1, EZH2, TBL1XR1, GRHL2, ZHX2, SPI1, HES1, IRF1, HDAC2, GATA2, TAF9B, NR2C2, RUNX1, BCL6, SMC1A, HDAC1, SIRT6, ZBTB24, CEBPA, AFF4, ZFX, SIN3A, SOX13, SMAD3, ZFP37, TWIST1, SMARCC1, MEF2A, ZBTB2, CREBBP, ZXDC, RARA, NOTCH1, RUNX2, CDK6, GATA4, PBX4, DAXX, ARNT, ATF2, HMBOX1, ZEB2, CBFA2T3, FOXM1, NR2C1, FOS, CDK8, CHD1, PBX3, ETV6, MED1, ZEB1, TEAD3, SPDEF, MYB, TERF1, SMAD1, NR1H2, KLF9, C11orf30, L3MBTL2, STAT5A, USF1, NIPBL, SP1, MAFK, HNF4A, NR4A1, BCL11A, REST, ARID1A, ATF7, ZHX1, PHIP, TCF3, AFF1, MBD2, FOXP1, BCOR, SMC3, ELL2, NCOR2, STAG1, STAG2, MLLT1, NFATC3, CBFA2T2, MEF2B, PPARG, FOXA2, MTA3, CREM, CHD2, PAF1, CBX3, ZNF316, EBF1, MAFF, ESR2, ZNF662, MEF2C, CDK9, HOXB13, ZNF318, KDM1A, YY1, RELA, JUNB, ZNF148, NEUROD1, TCF4, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, GATA1, CBX2, KLF4, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, TP53, ZNF687, MED, MYOD1, ELF3, BRD2, TBX21, BHLHE40, AR, YAP1, EGLN2, EGR1, MYNN, RNF2, NCOR1, BRD4, JUND, ILF3, CLOCK, CUX1, MAZ, IKZF2, MEF2D, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000205670, ENSG00000159216,
  • Related loop: chr21:34350000-34375000~~chr21:35225000-35250000, chr21:34766515-34767688~~chr21:35234194-35236987, chr21:34875000-34900000~~chr21:35225000-35250000, chr21:35050000-35075000~~chr21:35225000-35250000, chr21:35050055-35052229~~chr21:35226410-35228579, chr21:35050056-35052270~~chr21:35226396-35228810, chr21:35050370-35052249~~chr21:35226507-35228618, chr21:35188702-35190920~~chr21:35226847-35228785, chr21:35188826-35191178~~chr21:35226396-35228810, chr21:35225000-35250000~~chr21:35350000-35375000, chr21:35226847-35228785~~chr21:35339309-35341219, chr21:35226847-35228785~~chr21:35399325-35401608,
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