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Basic information

CohesinDB ID: CDBP00418016

Locus: chr21-35249249-35250292

Data sourse: ENCSR000BTQ, GSE206145-GSE177045, GSE72082, ENCSR000BSB, GSE129526, GSE76893, GSE68388, ENCSR703TNG, GSE25021, GSE115602

Cell type: MCF-7, HCT-116, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: NIPBL,SA1,Rad21,SMC1,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 82% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 61%, "9_Het": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, FOXA1, WDHD1, SMARCE1, ELF1, TEAD1, TRIM28, ZNF217, ESR1, HNF1B, JUN, TCF12, BAF155, EP300, MNT, SOX9, DPF2, TFAP2C, NANOG, POU5F1, CTBP1, ERF, DUX4, ERG, RAD21, GRHL3, GABPA, STAT3, NKX3-1, RCOR1, VDR, NR3C1, ESRRA, CEBPB, CREB1, GRHL2, ZHX2, HDAC2, GATA2, ZNF554, RUNX1, SMC1A, CBX1, SIN3A, SMAD3, CREBBP, ZXDC, GATA4, PBX4, ARNT, FOXM1, FOS, MED1, PIAS1, NIPBL, BCL11A, TFAP2A, ASH2L, CTBP2, MBD2, FOXP1, STAG1, HOXB13, KDM1A, RELA, TCF4, HIF1A, GATA3, MAX, NRIP1, ZNF143, TLE3, KLF4, NR2F2, KDM5B, TP53, ZNF334, ELF3, AR, ZNF579, EGLN2, JUND, BRD4, CUX1, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1,SETD4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159216, ENSG00000185917,

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Deatailed information for cohesin site CDBP00418016