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Basic information

CohesinDB ID: CDBP00418017

Locus: chr21-35252607-35260143

Data sourse: GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE103477, GSE111537, GSE131606, ENCSR330ELC, GSE108869, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE135093, GSE206145-NatGen2015, GSE138105, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE116344, GSE94872, ENCSR895JMI, GSE118494, ENCSR193NSH, ENCSR768DOX, ENCSR879KXD, ENCSR000EHW, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, GSE206145, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE131956, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS

Cell type: MDM, RH4, SLK, Liver, HuCC-T1, RPE, HMEC, Fibroblast, HEKn, HeLa-S3, IMR-90, K-562, HFFc6, DKO, SNYDER, MB157, GM12891, GBM39, SK-N-SH, RT-112, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, A-549, HUVEC, HCAEC, HeLa, OCI-AML-3, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 44% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.644

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 35%, "7_Enh": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NME2, FOXA1, MLL4, MEN1, ZBTB44, ZNF322, IKZF3, TEAD1, OCA2, MED26, PITX3, ZNF561, E4F1, DEK, ZNF528, NANOG, BRD3, POU5F1, ZNF263, CTBP1, ERF, DUX4, STAT1, ERG, ZBTB21, NFKB2, SMARCA4, RFX1, UBN1, ZNF398, RCOR1, DACH1, CEBPB, CREB1, ELF4, ZHX2, KLF17, GATA2, SIX2, FLI1, NR2C2, MXI1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, SMARCC1, PRDM10, ZNF549, ZXDC, ATF2, FOXM1, PIAS1, NR1H2, OVOL3, ELL2, MEF2B, CBX3, CREM, CHD2, SS18, PAF1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZFP36, BATF, SPIB, ZFP69B, KLF4, ELF3, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, FOSL1, ZNF660, XBP1, ZNF101, PBX2, ATF3, ZFP64, RUNX3, ZSCAN4, MITF, BACH2, ZNF467, MAF, JMJD1C, MYOG, ELF1, RBM39, SNAI2, JUN, CTCF, TAF3, ZBTB20, ZNF33A, DPF2, IRF4, TFAP2C, RBPJ, ZSCAN21, ZBTB17, ZBTB48, ZNF317, DDX5, CHD4, TSHZ1, ZNF2, FOXP2, LHX2, RXRA, BATF3, NKX3-1, VDR, NR3C1, ESRRA, STAT5B, FOXK1, KLF8, GRHL2, CTNNB1, ZBTB24, EZH2phosphoT487, AFF4, POU4F2, SP3, DAXX, ARNT, BACH1, ZEB2, NFYA, PBX3, ZNF10, TEAD3, ZXDB, ZNF680, KLF9, USF1, SP1, BCL11A, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, STAG1, STAG2, ZNF394, MAFF, KDM1A, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, TP53, NFKB1, ZSCAN22, BRD2, ARRB1, TBX21, RNF2, BRD4, JUND, CUX1, ZSCAN23, PGR, PATZ1, TFAP4, CHD7, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, SP4, TBP, HOXC5, ETS1, MYC, ZNF671, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, EZH2, ZNF652, SPI1, HDAC2, ZNF182, ZNF76, NFYB, ZNF554, ETV5, BCL6, SIN3A, ZBTB12, ERG3, MEF2A, CREBBP, ZNF384, ZNF35, HMGB2, ZNF518A, CBFA2T3, CDK8, ZEB1, MAFK, HNF4A, REST, ARID1A, ZHX1, BCOR, FOXP1, NCOR2, PPARG, ZNF692, ZNF30, ZNF574, ZNF823, RELA, MAX, ZNF592, TCF7L2, NEUROG2, KDM5B, NR2F1, MYOD1, AR, PAX3-FOXO1, YAP1, ZNF324, AHR, FOSL2, ZNF391, ZSCAN5C, E2F7, MEIS2, ZNF529, INSM2, NFIC, ZNF362, PRDM1, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, HNF1B, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, CREB3, E2F1, SMC1, TEAD4, CHD8, MYCN, SRC, ZNF205, ASCL1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF639, ARNTL, ZNF750, FEZF1, TRPS1, ZNF664, EHF, IRF1, ZNF766, MRTFB, MYF5, ATF1, CBX1, SMC1A, ZNF335, ZNF534, ZFX, SMAD3, CBX8, TWIST1, RUNX2, CDK6, GATA4, OSR2, ZNF184, GR, PBX4, NRF1, FOS, CHD1, MED1, ZNF558, MYB, SCRT2, L3MBTL2, SETDB1, KLF16, NIPBL, PHIP, ZNF283, FOXA2, ZNF600, FOXF1, CDK9, HOXB13, YY1, ZNF610, BRCA1, HIF1A, OTX2, TLE3, CEBPG, SP7, NR2F2, ZNF687, ZNF843, BHLHE40, TAF1, ZBTB42, MYNN, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1,SETD4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00418017