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Basic information

CohesinDB ID: CDBP00418019

Locus: chr21-35264418-35267579

Data sourse: GSE104888, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE121355, GSE103477, GSE131606, GSE108869, GSE25021, GSE165895, ENCSR000EFJ, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE206145-NatGen2015, GSE135093, GSE112028, GSE130135, GSE116344, ENCSR703TNG, GSE206145, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, ENCSR000ECS, GSE38411

Cell type: MDM, RH4, HuCC-T1, RPE, Fibroblast, HeLa-S3, IMR-90, K-562, BCBL-1, HFFc6, DKO, SK-N-SH, RT-112, HeLa-Tet-On, MCF-7, Hela-Kyoto, HCT-116, HEK293T, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 17% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.789

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 63%, "7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXA2, POU5F1, CRY1, SOX2, DUX4, FOXA1, HOXB13, TFAP4, RELA, PRDM1, PBX4, HIF1A, PROX1, GATA1, CDX2, NR3C1, SCRT2, TP53, OCA2, ESR1, GRHL2, ELF3, SPI1, EHF, BRD4, PHIP, SCRT1

Target gene symbol (double-evidenced CRMs): SETD4,RUNX1,SMIM11A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00418019