Browse_each

Basic information

CohesinDB ID: CDBP00418073

Locus: chr21-35374515-35378288

Data sourse: ENCSR000EFJ, ENCSR000HPG, ENCSR000BLY, GSE206145, GSE101921, GSE135093, GSE85526, GSE206145-NatGen2015, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE116344, GSE25021, GSE94872, ENCSR000ECS, GSE165895

Cell type: MCF-7, RPE, HMEC, Fibroblast, RH4, HEKn, HUVEC, HCAEC, HeLa-S3, IMR-90, SK-N-SH, K-562, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 8% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.844

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 65%, "7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SMC1A, FOXA2, NKX2-2, ZNF263, CEBPA, DUX4, SMAD3, ESR2, FOXA1, HOXB13, SMARCC1, ERG, RELA, CREBBP, JUNB, ETS1, RUNX2, NFIC, MYC, ATF3, RAD21, LHX2, PBX4, ARNT, ATF4, GATA3, PRDM9, HMGB2, ATF2, TAL1, PBX3, MAX, STAT3, GATA1, FOS, RCOR1, MED1, CDX2, VDR, NR3C1, CEBPG, CEBPB, NR2F2, TEAD1, CEBPD, ESR1, TP53, EBF3, MYOD1, JUN, TCF12, EP300, BHLHE40, AR, GATA2, REST, ATF7, BRD4, CTBP2, JUND, SMC1, TEAD4, STAG2, FOSL2

Target gene symbol (double-evidenced CRMs): CLIC6,RUNX1,SMIM11A

Function elements

Human SNPs: Waist-to-hip_ratio_adjusted_for_BMI

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159212, ENSG00000159216,

eachgene

Deatailed information for cohesin site CDBP00418073