- Basic information
- CohesinDB ID: CDBP00418078
- Locus: chr21-35394657-35397476
-
Data sourse: GSE67783, GSE86191, ENCSR000BSB, GSE138405, GSE25021, GSE111913, ENCSR000BLY, GSE206145, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, GSE68388, GSE83726, GSE103477, GSE116344, GSE131606, GSE94872, GSE165895
-
Cell type: MDM, RPE, Hela-Kyoto, Fibroblast, HCT-116, Hep-G2, Monocytes, RH4, HUVEC, HCAEC, RT-112, HSPC, SK-N-SH, K-562, HFFc6, HuCC-T1, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 10% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.811
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
81% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 42%,
"5_TxWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: RUNX1, FOXO1, SKI, BCL6, CEBPA, FOXA2, HMG20A, RUNX1T1, SOX13, ZSCAN16, SMAD3, FOXA1, MEF2C, CDK9, SMAD1-5, ERG, RELA, MYC, RUNX2, GATA4, RAD21, PBX4, PROX1, CBFB, GATA3, BATF3, GABPA, SMAD4, STAT3, MAX, XRCC5, CDK8, MED1, VDR, CEBPG, JMJD1C, CEBPB, TRIM28, MYB, RCOR2, ESR1, TP53, EVI1, STAT5A, BRD2, ZHX2, SPI1, BCL11A, TBX21, LMO1, AR, EP300, ZBTB16, HDAC2, RXR, GATA2, ZNF644, IRF4, TRIM24, FOSL2, BRD4, TCF3, NFIL3, TEAD4, GATAD2A, EED
- Target gene symbol (double-evidenced CRMs): CLIC6,RUNX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159212,
ENSG00000159216,
- Related loop:
chr21:34350000-34375000~~chr21:35400000-35425000,
chr21:34675000-34700000~~chr21:35400000-35425000,
chr21:34692471-34694305~~chr21:35399887-35401439,
chr21:34692480-34694427~~chr21:35399614-35401619,
chr21:34692573-34694447~~chr21:35399848-35401817,
chr21:34692731-34694389~~chr21:35399881-35401571,
chr21:34700000-34725000~~chr21:35375000-35400000,
chr21:34700000-34725000~~chr21:35400000-35425000,
chr21:34725000-34750000~~chr21:35400000-35425000,
chr21:34743262-34746775~~chr21:35399352-35402534,
chr21:34743512-34746717~~chr21:35399678-35401615,
chr21:34744447-34746791~~chr21:35399674-35401602,
chr21:34744498-34746753~~chr21:35399738-35401521,
chr21:34744530-34746777~~chr21:35399848-35401817,
chr21:34744539-34746791~~chr21:35399305-35401597,
chr21:34744561-34746765~~chr21:35399885-35401612,
chr21:34744567-34746780~~chr21:35399613-35401825,
chr21:34744580-34747072~~chr21:35399810-35401595,
chr21:34744581-34746732~~chr21:35399641-35401580,
chr21:34744589-34746918~~chr21:35399325-35401608,
chr21:34744631-34746764~~chr21:35399233-35401565,
chr21:34744640-34746731~~chr21:35399927-35401584,
chr21:34744749-34746554~~chr21:35399692-35401398,
chr21:34744771-34746620~~chr21:35399417-35401599,
chr21:34744773-34746587~~chr21:35399649-35401523,
chr21:34744780-34746750~~chr21:35399619-35401488,
chr21:34744790-34746552~~chr21:35399665-35401305,
chr21:34744815-34746785~~chr21:35398829-35401607,
chr21:34744836-34747063~~chr21:35398212-35401570,
chr21:34744840-34746785~~chr21:35399637-35401641,
chr21:34744848-34746795~~chr21:35399380-35401604,
chr21:34744884-34746937~~chr21:35399872-35401634,
chr21:34744887-34746720~~chr21:35399838-35401610,
chr21:34744917-34746726~~chr21:35399887-35401622,
chr21:34745037-34746426~~chr21:35399955-35401288,
chr21:34750000-34775000~~chr21:35400000-35425000,
chr21:34762299-34763454~~chr21:35399305-35401597,
chr21:34775000-34800000~~chr21:35400000-35425000,
chr21:34800491-34802782~~chr21:35399613-35401825,
chr21:34800561-34802971~~chr21:35399637-35401641,
chr21:34800597-34802977~~chr21:35399305-35401597,
chr21:34800640-34802930~~chr21:35399950-35401561,
chr21:34800647-34802985~~chr21:35399325-35401608,
chr21:34800839-34803321~~chr21:35399577-35401546,
chr21:34800869-34802601~~chr21:35399692-35401398,
chr21:34850000-34875000~~chr21:35375000-35400000,
chr21:34875000-34900000~~chr21:35375000-35400000,
chr21:34875000-34900000~~chr21:35400000-35425000,
chr21:34887476-34892097~~chr21:35399848-35401817,
chr21:34887491-34891013~~chr21:35399577-35401546,
chr21:34887508-34892091~~chr21:35399885-35401612,
chr21:34887510-34891018~~chr21:35399417-35401599,
chr21:34887518-34891075~~chr21:35399881-35401571,
chr21:34887552-34891083~~chr21:35399904-35401567,
chr21:34887571-34890954~~chr21:35399686-35401482,
chr21:34888052-34891094~~chr21:35399888-35401573,
chr21:34888113-34891105~~chr21:35399887-35401439,
chr21:34888151-34890935~~chr21:35399911-35401339,
chr21:34888177-34892032~~chr21:35399380-35401604,
chr21:34888325-34891071~~chr21:35399859-35401454,
chr21:34888362-34892029~~chr21:35399641-35401580,
chr21:34888802-34891093~~chr21:35399692-35401398,
chr21:34888858-34890919~~chr21:35399665-35401305,
chr21:34889120-34891504~~chr21:35399872-35401634,
chr21:34889124-34891177~~chr21:35399927-35401584,
chr21:34889146-34892075~~chr21:35399320-35401617,
chr21:34889149-34891526~~chr21:35399613-35401825,
chr21:34889184-34892059~~chr21:35399810-35401595,
chr21:34889188-34892063~~chr21:35399614-35401619,
chr21:34889198-34891559~~chr21:35399887-35401622,
chr21:34889210-34891617~~chr21:35399329-35401604,
chr21:34889215-34891125~~chr21:35399911-35401639,
chr21:34889215-34891491~~chr21:35399637-35401641,
chr21:34889220-34892087~~chr21:35398191-35399421,
chr21:34889220-34892087~~chr21:35399738-35401521,
chr21:34889223-34891142~~chr21:35399305-35401597,
chr21:34889230-34891145~~chr21:35399668-35401583,
chr21:34889231-34891534~~chr21:35399325-35401608,
chr21:34889242-34892124~~chr21:35399900-35402112,
chr21:34889251-34892128~~chr21:35399352-35402534,
chr21:34889254-34891157~~chr21:35399838-35401610,
chr21:34889261-34891776~~chr21:35398829-35401607,
chr21:34889270-34892070~~chr21:35399625-35402389,
chr21:34889280-34891141~~chr21:35399667-35401542,
chr21:34889297-34891513~~chr21:35399678-35401615,
chr21:34889298-34892087~~chr21:35399898-35401583,
chr21:34889303-34891098~~chr21:35399841-35401521,
chr21:34889367-34892315~~chr21:35398021-35401583,
chr21:34889427-34892109~~chr21:35398212-35401570,
chr21:34889484-34890922~~chr21:35399886-35401254,
chr21:34889494-34891026~~chr21:35399649-35401523,
chr21:34889504-34891012~~chr21:35399885-35401523,
chr21:34900000-34925000~~chr21:35375000-35400000,
chr21:34900000-34925000~~chr21:35400000-35425000,
chr21:34911078-34913334~~chr21:35399305-35401597,
chr21:35025000-35050000~~chr21:35375000-35400000,
chr21:35025000-35050000~~chr21:35400000-35425000,
chr21:35046393-35049585~~chr21:35389509-35390697,
chr21:35046404-35049739~~chr21:35399865-35402075,
chr21:35046419-35049571~~chr21:35399320-35401617,
chr21:35046426-35049481~~chr21:35389494-35391077,
chr21:35046648-35047882~~chr21:35399352-35402534,
chr21:35046768-35049526~~chr21:35398212-35401570,
chr21:35048216-35049984~~chr21:35399305-35401597,
chr21:35048680-35049910~~chr21:35399329-35401604,
chr21:35050000-35075000~~chr21:35375000-35400000,
chr21:35050000-35075000~~chr21:35400000-35425000,
chr21:35050018-35052226~~chr21:35399305-35401597,
chr21:35050018-35052259~~chr21:35399872-35401634,
chr21:35050055-35052229~~chr21:35399613-35401825,
chr21:35050056-35052270~~chr21:35399637-35401641,
chr21:35050107-35052241~~chr21:35399417-35401599,
chr21:35050211-35052170~~chr21:35399577-35401546,
chr21:35050233-35052173~~chr21:35399465-35401485,
chr21:35050273-35052269~~chr21:35399325-35401608,
chr21:35050316-35052108~~chr21:35399665-35401305,
chr21:35050328-35052241~~chr21:35398177-35399626,
chr21:35050328-35052241~~chr21:35399900-35402112,
chr21:35050349-35052147~~chr21:35399329-35401604,
chr21:35050353-35052253~~chr21:35399885-35401612,
chr21:35050371-35052276~~chr21:35399649-35401523,
chr21:35050379-35052311~~chr21:35399352-35402534,
chr21:35050382-35052264~~chr21:35399641-35401580,
chr21:35050390-35052342~~chr21:35399848-35401817,
chr21:35050395-35052265~~chr21:35399674-35401602,
chr21:35050403-35052138~~chr21:35399885-35401523,
chr21:35050423-35052303~~chr21:35399887-35401622,
chr21:35050426-35052300~~chr21:35399625-35402389,
chr21:35050457-35052097~~chr21:35399888-35401573,
chr21:35050457-35052285~~chr21:35398212-35401570,
chr21:35050481-35052295~~chr21:35399614-35401619,
chr21:35050491-35052225~~chr21:35399841-35401521,
chr21:35050508-35052311~~chr21:35399725-35401527,
chr21:35050528-35052327~~chr21:35399898-35401583,
chr21:35050531-35052287~~chr21:35399738-35401521,
chr21:35050594-35052075~~chr21:35399881-35401571,
chr21:35052915-35054121~~chr21:35398829-35401607,
chr21:35125000-35150000~~chr21:35375000-35400000,
chr21:35136308-35139866~~chr21:35398829-35401607,
chr21:35200000-35225000~~chr21:35375000-35400000,
chr21:35200000-35225000~~chr21:35400000-35425000,
chr21:35226847-35228785~~chr21:35399325-35401608,
chr21:35250000-35275000~~chr21:35375000-35400000,
chr21:35275000-35300000~~chr21:35375000-35400000,
chr21:35375000-35400000~~chr21:35825000-35850000,
chr21:35398212-35401570~~chr21:35839090-35841121,
chr21:35399380-35401604~~chr21:35838708-35841092,
chr21:35399881-35401571~~chr21:36027315-36029474,
chr21:35399885-35401612~~chr21:35939344-35941327,
chr21:35400000-35425000~~chr21:35500000-35525000,
chr21:35400000-35425000~~chr21:35525000-35550000,
chr21:35400000-35425000~~chr21:35575000-35600000,
chr21:35400000-35425000~~chr21:35600000-35625000,
chr21:35400000-35425000~~chr21:35625000-35650000,
chr21:35400000-35425000~~chr21:35825000-35850000,
chr21:35400000-35425000~~chr21:35925000-35950000,
chr21:35400000-35425000~~chr21:36025000-36050000,