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Basic information

CohesinDB ID: CDBP00418121

Locus: chr21-35505813-35513273

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE131577, GSE64758, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, THP-1, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, SC, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 65% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.289

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 80% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 36%, "15_Quies": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, SOX2, MEIS2, HNF1A, XBP1, FOXA1, HLF, SUZ12, PBX2, RXRB, TFAP4, ZNF90, ATF3, NFIC, BMI1, CTCFL, CHD7, PRDM1, WDHD1, ATF4, MORC2, MXD4, MECOM, SMARCE1, PAX5, MYOG, JMJD1C, TEAD1, TRIM28, KLF6, NFE2L2, RCOR2, ESR1, HNF1B, LMO2, OCA2, MLL, USF2, CTCF, TCF12, JUN, EP300, KLF1, MNT, SOX5, DPF2, E2F6, TRIM24, RFX5, IRF4, SOX6, DEK, ZNF410, SMC1, TEAD4, KMT2B, FOXA3, ZNF92, GATAD2A, TFAP2C, RBPJ, MLX, NANOG, POU2F2, POU5F1, MYCN, RUNX1T1, ID3, CTBP1, DUX4, STAT1, MLLT3, GATAD1, SAP130, NBN, ARID3A, HNF4G, ERG, CHD4, PBX1, MYC, EOMES, ARID1B, RAD21, HOMEZ, RXRA, NKX2-1, FOXK2, PROX1, STAT3, XRCC5, ZNF614, PRDM14, IKZF1, RCOR1, NFE2, NR2F6, MIER3, VDR, NR3C1, CEBPB, ESRRA, KMT2A, CREB1, CCAR2, EZH2, TBL1XR1, JMJD6, GRHL2, SPI1, MIXL1, TFE3, IRF1, HDAC2, GATA2, INTS13, ZNF644, GATAD2B, SIX2, FLI1, HCFC1, NR2C2, MXI1, DRAP1, SMARCA5, EP400, NFIL3, NCOA2, MYF5, ATF1, ETV5, CC2D1A, RUNX1, THAP11, MAFG, SMC1A, HDAC1, CEBPA, CBX1, BCL6, SOX13, ZFX, SIN3A, AFF4, SMAD3, TRIM22, TWIST1, ZNF18, SMARCC1, PRDM10, ZBTB2, ZNF384, ZXDC, RARA, IRF2, CREBBP, RUNX2, SMAD2, GATA4, CDK6, ZNF184, NRF1, DAXX, ARNT, PBX4, ATF2, PRDM9, HMBOX1, NFYA, SMAD4, PBX3, ZNF48, NR2C1, ETV6, CDK8, HMGXB4, FOS, FOXM1, MED1, TEAD3, PML, CEBPD, MYB, ZMYM3, SMAD1, KLF9, C11orf30, L3MBTL2, EVI1, MAFK, SP1, BCL11A, TFAP2A, HNF4A, NR4A1, IKZF5, REST, ZBTB7A, RBM25, POU2F3, ATF7, ASH2L, ZHX1, CTBP2, PHIP, BCOR, TCF3, FOXP1, SMC3, MLLT1, STAG1, SKI, CBFA2T2, PPARG, ZNF207, CBX3, FOXA2, CREM, MIER2, MEF2C, CDK9, HOXB13, ZNF580, ZKSCAN1, KDM1A, YY1, RELA, JUNB, NEUROD1, CHAMP1, HIF1A, SKIL, GATA3, MGA, TAL1, MAX, NRIP1, GATA1, ZNF143, KLF4, ZNF592, CEBPG, GFI1B, NR2F2, NR2F1, TCF7L2, KDM5B, NEUROG2, TP53, PKNOX1, MYOD1, ELF3, T, BRD2, KAT8, ARID4B, BHLHE40, AR, ZBTB40, RXR, RB1, MYNN, NCOR1, HSF1, BRD4, ILF3, JUND, ZBTB26, MAZ, IRF9, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): SETD4,CLIC6,SMIM11A,RUNX1

Function elements

Human SNPs: Heel_bone_mineral_density

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00418121