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Basic information

CohesinDB ID: CDBP00418123

Locus: chr21-35520216-35522630

Data sourse: ENCSR000BLD, ENCSR000BKV, GSE86191, GSE25021, ENCSR000BLY, ENCSR879KXD, GSE105028, GSE206145-NatGen2015, ENCSR000ECE, GSE206145, ENCSR153HNT, GSE83726, GSE116344, GSE106870, GSE145327, GSE97394, GSE64758

Cell type: H1-hESC, Fibroblast, HCT-116, RH4, HEK293T, Hep-G2, HUES64, K-562, SK-N-SH, CVI-hiPSC, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: NIPBL,SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 80% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 67%, "7_Enh": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: SOX2, NME2, MEIS2, FOXA1, PBX2, CHD7, ZSCAN4, TP63, CDX2, TRIM28, ESR1, OCA2, TP73, CTCF, TCF12, JUN, BAF155, GATA6, ZNF350, TEAD4, PDX1, TFAP2C, NANOG, CHD8, ZSCAN5D, MYCN, POU5F1, CTBP1, ZNF317, DUX4, ZNF134, SP4, ERG, MYC, SMARCA4, RFX1, ARID1B, RAD21, GRHL3, STAT3, XRCC5, IKZF1, RCOR1, NR3C1, CREB1, EZH2, HDAC2, GATA2, RUNX1, CTNNB1, SMC1A, HDAC1, EZH2phosphoT487, ZFX, SMAD3, CBX8, ERG3, ZNF18, ZNF384, NOTCH1, NRF1, ARNT, ATF2, ZNF518A, CBFA2T3, ZNF10, FOS, MED1, MYB, SCRT2, NIPBL, BCL11A, HNF4A, NR4A1, RBM25, ATF7, POU2F3, ASH2L, HNRNPLL, BCOR, FOXP1, CBFA2T2, PPARG, FOXA2, ZNF207, CREM, MEIS1, RBBP5, WT1, HOXB13, KDM1A, YY1, RELA, MCM3, HIF1A, TAL1, MAX, NRIP1, ZNF143, GATA1, GFI1B, TCF7L2, TP53, PKNOX1, AR, ZBTB16, RNF2, BRD4, JUND, MAZ

Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1,SETD4,CLIC6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00418123