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Basic information

CohesinDB ID: CDBP00418135

Locus: chr21-35573981-35576315

Data sourse: ENCSR000EFJ, ENCSR230ZWH, GSE165895, ENCSR000HPG, ENCSR000BLY, GSE206145, GSE206145-NatGen2015, GSE135093, GSE130135, ENCSR917QNE

Cell type: Fibroblast, HEK293T, IMR-90, SK-N-SH, Liver, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 80% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 60%, "14_ReprPCWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: SKI, FOXO1, BCL6, ZNF316, HMG20A, FOXA2, CEBPA, SOX13, ZBTB17, MAFF, FOXA1, CBX8, RXRB, HOXB13, KDM1A, RELA, RARA, RUNX2, RAD21, PRDM1, ARNT, PBX4, RXRA, HMGB2, SMAD4, MXD4, MAX, IKZF1, NR2F6, MED1, CBX2, NR3C1, CEBPB, CEBPG, TEAD3, NR2F2, TEAD1, ESR1, C11orf30, FEZF1, ELF3, MAFK, EP300, SPI1, MIXL1, HNF4A, AR, IKZF5, ELL2, RNF2, NCOR1, BRD4, PHIP, FOXA3, GATAD2A, RBPJ

Target gene symbol (double-evidenced CRMs): CLIC6,RUNX1,SETD4,SMIM11A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159212, ENSG00000159216, ENSG00000185917,

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Deatailed information for cohesin site CDBP00418135