Deatailed information for cohesin site CDBP00418140

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  • Basic information
  • CohesinDB ID: CDBP00418140
  • Locus: chr21-35585360-35587069
  • Data sourse: ENCSR230ZWH, GSE138405, GSE129526, GSE206145, ENCSR000ECS, ENCSR917QNE
  • Cell type: Hela-Kyoto, HCT-116, HEK293T, HeLa-S3, Liver
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 3% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.944
  • Subunit: NIPBL,SMC3,Rad21,SA2
  • CTCF binding site: non-CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 80% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 49%, "14_ReprPCWk": 26%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, FOSL1, ZNF391, PGR, ZNF426, HMG20A, ZNF660, E2F7, ZNF621, MEIS2, NME2, XBP1, SOX2, ZSCAN5C, ZNF101, FOXA1, PATZ1, HLF, PBX2, RXRB, ZFHX2, ZNF596, INSM2, ATF3, NFIC, ZFP64, ZNF362, CHD7, ZBTB44, PRDM1, IKZF3, RUNX3, KLF14, ATF4, MXD4, ZNF189, ZSCAN4, MITF, BACH2, CDX2, ZNF629, MAF, TEAD1, ZNF121, TRIM28, ZNF26, KLF6, NFE2L2, KLF10, ZNF624, ESR1, OCA2, HNF1B, HDAC8, USF2, ZNF561, JUN, TCF12, CTCF, EP300, SND1, ZNF577, BAF155, SOX5, DPF2, PAX8, PRDM4, TRIM24, IRF4, CREB3, E2F4, ZNF423, E2F1, ZNF528, ZNF350, TEAD4, ZNF92, FOXA3, GATAD2A, PDX1, TFAP2C, EHMT2, RBPJ, MLX, GLIS1, POU2F2, BRD3, HHEX, ZNF778, CDK7, ID3, POU5F1, ZSCAN21, ZBTB17, DUX4, ZSCAN5A, ZBTB1, ERF, KDM4C, ZNF488, ZNF317, SAP130, ERG2, ARID3A, HIC1, SP4, ERG, ZBTB21, KLF4, ZBTB8A, MYC, ONECUT1, SMARCA4, ZNF2, ARID1B, RAD21, GRHL3, RXRA, BATF3, STAT3, XRCC5, ZNF398, IKZF1, RCOR1, NFE2, ZNF639, NFRKB, VDR, NR2F6, NR3C1, CEBPB, ZNF750, ESRRA, KMT2A, CREB1, EZH2, KLF8, GRHL2, FEZF1, ZNF652, SPI1, ZNF664, MIXL1, TFE3, IRF1, HDAC2, GATA2, ZNF644, ZNF146, FLI1, NR2C2, ZNF76, SALL2, RUNX1, MAFG, BCL6, CEBPA, CRY1, AFF4, ZFX, SOX13, SMAD3, CBX8, ERG3, ZNF513, SMARCC1, ZNF18, PRDM10, MYBL2, RARA, ZNF384, ZNF35, RUNX2, CDK6, ZSCAN30, OSR2, ZNF184, GATA4, SMAD2, NRF1, PBX4, ARNT, BACH1, ATF2, PRDM9, ZEB2, ZNF518A, SMAD4, PBX3, FOXM1, SP2, CHD1, FOS, CDK8, ZNF10, CBFA2T3, MED1, TEAD3, ZEB1, ZXDB, MYB, SCRT2, CEBPD, ZMYM3, KLF9, C11orf30, L3MBTL2, NUP98-HOXA9, USF1, MAFK, BCL11A, SP1, NR4A1, HNF4A, REST, ZBTB7A, GLI2, ZNF479, RBM25, OVOL3, POU2F3, PHIP, BCOR, FOXP1, PRDM6, ZNF623, SMC3, ELL2, ZNF34, ZNF394, PAX7, SKI, KLF13, MEF2B, FOXA2, MTA3, PPARG, CHD2, SS18, TBL1X, ZNF600, ZNF692, GTF2B, MAFF, WT1, FOXF1, ZNF662, ZBTB33, TCF7, CDK9, YY2, HOXB13, ZNF580, KLF7, KDM1A, YY1, RELA, ZNF19, JUNB, ZNF148, KAT2B, ZIC2, HIF1A, GATA3, BATF, MGA, TAL1, MAX, SPIB, ZNF143, GATA1, ZNF449, NRIP1, CBX2, CEBPG, ZFP69B, SP7, GFI1B, NR2F2, NCOA3, ZNF592, ZNF544, NR2F1, TCF7L2, BCL11B, SMAD1-5-8, ZBTB6, ZNF213, PKNOX1, ZNF334, BCL6B, NFKB1, EGR2, PHOX2B, BRD2, ZNF843, ELF3, BHLHE40, AR, TAF1, ZBTB40, ZNF324, ZNF366, EGR1, RNF2, NOTCH3, BRD4, JUND, SCRT1, CUX1, MAZ, ZSCAN23, ZNF24, ZNF316, FOSL2
  • Target gene symbol (double-evidenced CRMs): CLIC6,SMIM11A,SETD4,RUNX1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 2
  • Related genes and loops
  • Related gene: ENSG00000205670, ENSG00000159212, ENSG00000159216, ENSG00000185917,
  • Related loop: chr21:34350000-34375000~~chr21:35575000-35600000, chr21:34675000-34700000~~chr21:35575000-35600000, chr21:34875000-34900000~~chr21:35575000-35600000, chr21:35250000-35275000~~chr21:35575000-35600000, chr21:35400000-35425000~~chr21:35575000-35600000, chr21:35450000-35475000~~chr21:35575000-35600000, chr21:35575000-35600000~~chr21:35825000-35850000, chr21:35575000-35600000~~chr21:36025000-36050000,
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