- Basic information
- CohesinDB ID: CDBP00418152
- Locus: chr21-35613404-35617826
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE93080, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, GSE126755, ENCSR748MVX, ENCSR000ECS, ENCSR000BLD, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE76893, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE110061, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, GM19240, OCI-AML-3, Liver, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 54% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.389
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 46%,
"7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: CEBPB, RAD21, RNF2, ARNT, GRHL3, PHIP, MEF2C, MAF1, PBX2, SPI1
- Target gene symbol (double-evidenced CRMs): RCAN1,SMIM11A,RUNX1,CLIC6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000159200,
ENSG00000159212,
ENSG00000159216,
- Related loop:
chr21:34350000-34375000~~chr21:35600000-35625000,
chr21:34500000-34525000~~chr21:35600000-35625000,
chr21:34675000-34700000~~chr21:35600000-35625000,
chr21:34692384-34694384~~chr21:35615361-35617172,
chr21:34722101-34723694~~chr21:35615336-35617186,
chr21:34725000-34750000~~chr21:35600000-35625000,
chr21:34744530-34746777~~chr21:35614293-35617009,
chr21:34744561-34746765~~chr21:35615361-35617172,
chr21:34744567-34746780~~chr21:35615336-35617206,
chr21:34744589-34746918~~chr21:35615292-35617215,
chr21:34744771-34746620~~chr21:35615456-35617044,
chr21:34744787-34746612~~chr21:35615562-35617011,
chr21:34744840-34746785~~chr21:35615343-35617201,
chr21:34744884-34746937~~chr21:35615517-35617148,
chr21:34750000-34775000~~chr21:35600000-35625000,
chr21:34875000-34900000~~chr21:35600000-35625000,
chr21:34887476-34892097~~chr21:35614293-35617009,
chr21:34887508-34892091~~chr21:35615361-35617172,
chr21:34887510-34891018~~chr21:35615456-35617044,
chr21:34887533-34888841~~chr21:35614050-35617694,
chr21:34888177-34892032~~chr21:35615399-35616943,
chr21:34889184-34892059~~chr21:35615365-35617187,
chr21:34889215-34891491~~chr21:35615343-35617201,
chr21:34889427-34892109~~chr21:35614047-35617200,
chr21:35050390-35052342~~chr21:35614293-35617009,
chr21:35400000-35425000~~chr21:35600000-35625000,
chr21:35425000-35450000~~chr21:35600000-35625000,
chr21:35600000-35625000~~chr21:35925000-35950000,