- Basic information
- CohesinDB ID: CDBP00418164
- Locus: chr21-35642894-35644306
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Data sourse: GSE67783, GSE138405, GSE101921, GSE135093, GSE85526, GSE206145-NatGen2015, GSE68388, GSE116344, GSE131606, GSE108869, GSE94872
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Cell type: Hela-Kyoto, Fibroblast, RH4, HEKn, HUVEC, HCAEC, HeLa-S3, IMR-90, HSPC, HuCC-T1, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.878
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 47%,
"14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, MAFG, SMC1A, ZFX, GTF2B, ZBTB48, SMAD3, FOXA1, CDK9, ERG, RELA, JUNB, ETS1, RUNX2, MYC, GATA4, ATF3, RAD21, MCM3, PBX4, NKX2-1, GATA3, TAL1, STAT3, FOS, CDK8, RCOR1, MED1, VDR, NR3C1, MYOG, ESRRA, CEBPB, TEAD1, TRIM28, SNAI2, TP53, C11orf30, MYOD1, BRD2, JUN, MAFK, SPI1, CTCF, AR, SOX4, GATA2, FLI1, BRD4, JUND, E2F1, SMC1, TEAD4, STAG2, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): SETD4,SMIM11A,RUNX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000159216,
ENSG00000185917,
- Related loop:
chr21:27000000-27025000~~chr21:35625000-35650000,
chr21:34350000-34375000~~chr21:35625000-35650000,
chr21:34692406-34694411~~chr21:35648041-35649435,
chr21:34875000-34900000~~chr21:35625000-35650000,
chr21:34887508-34892091~~chr21:35642873-35644084,
chr21:35400000-35425000~~chr21:35625000-35650000,
chr21:35625000-35650000~~chr21:35825000-35850000,
chr21:35625000-35650000~~chr21:35925000-35950000,
chr21:35625000-35650000~~chr21:36025000-36050000,