- Basic information
- CohesinDB ID: CDBP00418166
- Locus: chr21-35648338-35649581
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, GSE103477, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, GSE115602, GSE165895, ENCSR000EAC, GSE93080, ENCSR000BKV, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE112028, GSE138105, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, ENCSR000EEG, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, GSE55407, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR000EDE, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS
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Cell type: MDM, RH4, GM2610, SLK, CVB-hiPSC, GM19240, Liver, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, GM18505, MB157, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, HUVEC, HCAEC, GM19238, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 28% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.489
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 50%,
"14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, XBP1, FOXA1, TFAP4, ATF3, MAF, MYOG, TEAD1, ESR1, OCA2, CTCF, TCF12, JUN, BAF155, E2F6, E2F1, SMC1, TFAP2C, GLIS1, NANOG, ZNF263, TOP2A, ERG, HOXC5, ASCL1, MYC, RAD21, GRHL3, RXRA, GABPA, STAT3, NKX3-1, ARNTL, NR3C1, CREB1, GRHL2, GATA2, INTS13, CTNNB1, SMC1A, CBX1, SIN3A, ZFX, ERG3, CREBBP, ZNF384, ZBTB2, RUNX2, GATA4, ARNT, PBX4, ZNF10, FOS, CDK8, MED1, PIAS1, SP1, HNF4A, ARID2, FOXP1, SMC3, STAG2, STAG1, FOXA2, HOXB13, RELA, ZIC2, HIF1A, GATA3, TAL1, MAX, TLE3, NCOA3, KDM5B, TP53, ELF3, BRD2, BHLHE40, AR, EGLN2, BRD4, JUND, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1,CLIC6,SETD4
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000159212,
ENSG00000159216,
ENSG00000185917,
- Related loop:
chr21:27000000-27025000~~chr21:35625000-35650000,
chr21:34350000-34375000~~chr21:35625000-35650000,
chr21:34350000-34375000~~chr21:35650000-35675000,
chr21:34692406-34694411~~chr21:35648041-35649435,
chr21:34875000-34900000~~chr21:35625000-35650000,
chr21:34887508-34892091~~chr21:35642873-35644084,
chr21:35400000-35425000~~chr21:35625000-35650000,
chr21:35625000-35650000~~chr21:35825000-35850000,
chr21:35625000-35650000~~chr21:35925000-35950000,
chr21:35625000-35650000~~chr21:36025000-36050000,
chr21:35650000-35675000~~chr21:35825000-35850000,
chr21:35650000-35675000~~chr21:35925000-35950000,
chr21:35652140-35653632~~chr21:35931764-35934473,