- Basic information
- CohesinDB ID: CDBP00418176
- Locus: chr21-35678421-35678743
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Data sourse: GSE120943, GSE98367
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Cell type: Monocytes, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 60%,
"14_ReprPCWk": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, SOX2, ZNF621, FOXA1, TFAP4, HDGF, MEN1, ATF3, BMI1, MXD4, SMARCE1, TP63, TEAD1, ELF1, ZNF217, ESR1, CTCF, TCF12, EP300, MNT, SOX5, DPF2, RAD51, ZNF776, E2F1, ZNF528, TEAD4, EHMT2, TFAP2C, POU5F1, HHEX, CTBP1, ZSCAN21, ZBTB17, SAP130, HNF4G, ZBTB21, RFX1, RAD21, GRHL3, RXRA, GABPA, STAT3, ZNF398, ZNF750, ESRRA, CEBPB, NR3C1, CREB1, GRHL2, SPI1, MIXL1, HDAC2, NCOA2, BCL6, CBX1, CEBPA, HDAC1, CRY1, SIN3A, ZFX, SMAD3, ZNF473, RARA, CREBBP, ZXDC, RUNX2, PBX4, ARNT, NFIB, SMAD4, FOXM1, FOS, TEAD3, SP1, TFAP2A, HNF4A, REST, ASH2L, CTBP2, MBD2, FOXP1, STAG1, MLLT1, SKI, FOXA2, ZNF662, ZBTB33, CDK9, ZNF580, KDM1A, YY1, RELA, TARDBP, MCM3, HIF1A, GATA3, MAX, NRIP1, ZNF143, MTA1, TLE3, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, TP53, PKNOX1, ZNF687, AR, PAX3-FOXO1, YAP1, ZNF366, EGR1, JUND, CUX1, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): SETD4,SMIM11A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000185917,
- Related loop:
chr21:34300000-34325000~~chr21:35675000-35700000,
chr21:34350000-34375000~~chr21:35650000-35675000,
chr21:34350000-34375000~~chr21:35675000-35700000,
chr21:35510785-35512091~~chr21:35676592-35678756,
chr21:35650000-35675000~~chr21:35825000-35850000,
chr21:35650000-35675000~~chr21:35925000-35950000,
chr21:35674462-35675960~~chr21:35839090-35841121,
chr21:35675000-35700000~~chr21:35775000-35800000,
chr21:35675000-35700000~~chr21:35825000-35850000,
chr21:35675000-35700000~~chr21:35925000-35950000,
chr21:35675000-35700000~~chr21:36025000-36050000,