- Basic information
- CohesinDB ID: CDBP00418195
- Locus: chr21-35737764-35739257
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Data sourse: GSE86191, GSE138405, GSE116868, ENCSR000BLY, GSE85526, GSE206145-NatGen2015, GSE68388, GSE130135, GSE111537, GSE126990, GSE165895
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Cell type: Hela-Kyoto, Fibroblast, HCT-116, HEKn, HEK293T, MB157, SK-N-SH, OCI-AML-3, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
80% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 50%,
"7_Enh": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, SOX2, XBP1, FOXA1, ATF3, NFIC, RUNX3, CBFB, PAX5, TP63, JMJD1C, ETV1, ESR1, MLL, CTCF, JUN, TCF12, BAF155, ZNF528, KMT2B, PDX1, TFAP2C, CHD8, ZNF263, TOP2A, ERF, ZBTB48, SRF, MLLT3, TBP, ERG, HOXC5, PAX6, PBX1, SMARCC2, ETS1, EZH1, SMARCA4, RAD21, LHX2, GRHL3, NKX2-1, GABPA, STAT3, GFI1, IKZF1, VDR, NR3C1, CEBPB, ESRRA, KMT2A, EZH2, ZHX2, SPI1, EHF, IRF1, GATA2, SIX2, FLI1, MRTFB, RUNX1, SMC1A, CEBPA, ZFX, SMAD3, SMARCC1, CREBBP, RUNX2, CDK6, PBX4, DAXX, ARNT, PBX3, FOS, SMARCB1, MED1, MYB, BCL11A, ARID1A, PHIP, TCF3, SMC3, MLLT1, PPARG, EBF1, MEIS1, SS18, WT1, MEF2C, CDK9, HOXB13, RELA, ZIC2, OTX2, GATA3, MAX, CEBPG, NR2F2, NR2F1, KDM5B, TP53, MED, ELF3, AR, BRD4, JUND, MAZ, ZNF24, FOSL2
- Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A
- Function elements
- Human SNPs: Left_ventricle_wall_thickness
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 1
- Related genes and loops