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Basic information

CohesinDB ID: CDBP00418229

Locus: chr21-35837818-35843127

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, HeLa, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 78% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.133

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 52%, "14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, HMG20A, ZNF660, SOX2, XBP1, FOXA1, PBX2, RXRB, KDM3A, CTCFL, MXD4, ZNF189, CDX2, TEAD1, BCLAF1, SNAI2, ZNF79, ESR1, OCA2, CTCF, JUN, BAF155, LMO1, GATA6, IRF4, TRIM24, SMC1, TEAD4, FOXA3, KMT2B, GATAD2A, PDX1, TFAP2C, RBPJ, POU2F2, NANOG, POU5F1, TOP2A, CDK7, ZNF317, DUX4, SRF, GATAD1, DDX5, ERG2, ZNF300, ERG, HOXC5, ASCL1, MYC, EOMES, SMARCA4, HOMEZ, RAD21, GRHL3, PROX1, RXRA, FOXK2, NKX2-1, GABPA, STAT3, NKX3-1, ZNF639, NR3C1, CEBPB, CREB1, EZH2, TBL1XR1, KLF8, SPI1, TFE3, MIXL1, IRF1, HDAC2, GATA2, FLI1, NFIL3, NFYB, RUNX1, THAP11, SMC1A, BCL6, NKX2-2, CRY1, AFF4, ZFX, SMAD3, ZNF654, SP5, TRIM22, SMARCC1, ZBTB2, ZNF35, NOTCH1, ZNF384, RUNX2, GATA4, GR, ZNF184, PBX4, PRDM9, ZNF518A, CBFA2T3, ETV6, NR2C1, ZNF10, CDK8, CHD1, HMGXB4, MED1, ZEB1, TERF1, MYB, SCRT2, PIAS1, SMAD1, TBX5, KLF16, BCL11A, HNF4A, NKX2-5, REST, RBM25, ASH2L, PHIP, SMC3, STAG1, STAG2, ZNF394, PPARG, FOXA2, CBX3, EBF1, MEIS1, SS18, ZNF692, GTF2B, MEF2C, CDK9, HOXB13, YY1, RELA, HIF1A, SKIL, OTX2, GATA3, TAL1, MAX, NRIP1, GATA1, ZNF143, KLF4, BCL11B, SP7, TCF7L2, KDM5B, TP53, T, PHF5A, KAT8, ELF3, BRD2, AR, EGLN2, BRD4, ILF3, SCRT1, JUND, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): SMIM11A,SETD4,RCAN1,CLIC6,RUNX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00418229