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Basic information

CohesinDB ID: CDBP00418231

Locus: chr21-35849614-35851658

Data sourse: GSE67783, GSE86191, ENCSR000HPG, ENCSR000BLY, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE165895

Cell type: RPE, Fibroblast, HCT-116, IMR-90, SK-N-SH, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 34%, "14_ReprPCWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, ZNF239, POU5F1, TOP2A, SOX2, SS18, ZFX, ERG2, RELA, GATA4, GATA3, TAL1, FOS, GATA1, MED1, NR3C1, CEBPB, KLF4, CREB1, EZH2, BHLHE40, GATA2, ZNF548, BRD4, NR1H3

Target gene symbol (double-evidenced CRMs): RCAN1,SETD4,RUNX1,CLIC6,SMIM11A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917,

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Deatailed information for cohesin site CDBP00418231