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Basic information

CohesinDB ID: CDBP00418252

Locus: chr21-35931956-35934271

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000DZP, GSE93080, ENCSR000BKV, GSE86191, GSE138405, GSE101921, GSE135093, GSE152721, GSE120943, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE116344, GSE145327, GSE94872, GSE76815, GSE98367, ENCSR193NSH, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, GSE206145, ENCSR000BMY, ENCSR000EHX, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR853VWZ, GSE55407, GSE131956, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM2610, OCI-AML-3, Liver, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, GM12878, GM12891, GM2588, GBM39, SK-N-SH, RT-112, HeLa-Tet-On, THP-1, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, GM19238, HeLa, Neutrophil, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 32% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.478

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 34%, "15_Quies": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, ZNF660, SOX2, NME2, XBP1, HNF1A, ZNF101, FOXA1, SUZ12, MLL4, ZFHX2, TFAP4, LYL1, ATF3, NFIC, ZNF362, CTCFL, RUNX3, PRDM1, CHD7, CBFB, ZNF189, MECOM, PAX5, MZF1, ZSCAN4, BACH2, ZNF629, JMJD1C, MYOG, TEAD1, TRIM28, BCLAF1, KLF6, ETV1, ELF1, SNAI2, LMO2, ESR1, MLL, ZFP91, JUN, TCF12, CTCF, EP300, KLF1, SOX4, TRIM24, IRF4, E2F1, SMC1, TEAD4, KMT2B, RBPJ, EED, TFAP2C, GLIS1, POU2F2, MYCN, BRD3, TOP2A, ID3, RUNX1T1, POU5F1, ZSCAN21, ZBTB17, ZNF317, ZBTB48, STAT1, DUX4, SRF, MLLT3, ERG2, HNF4G, HOXC5, ZBTB21, ERG, PBX1, ASCL1, ETS1, MYC, SMARCA4, TSHZ1, HOMEZ, RAD21, GRHL3, PROX1, RXRA, NKX2-1, GABPA, STAT3, APC, UBN1, IKZF1, RCOR1, NFE2, NR2F6, ZNF639, VDR, NR3C1, CEBPB, ZNF750, ESRRA, KMT2A, CREB1, EZH2, KLF8, GRHL2, EBF3, MRTFA, ZHX2, SPI1, EHF, IRF1, KLF17, GATA2, INTS13, ZNF644, ZNF182, FLI1, ZNF766, HEXIM1-CDK9, MRTFB, NCOA2, ZNF554, RUNX1, SMC1A, ZBTB24, MAFG, BCL6, CEBPA, SOX13, ZFX, SIN3A, AFF4, SMAD3, ERG3, SMARCC1, PRDM10, ZNF549, MEF2A, TWIST1, RARA, ZNF35, CREBBP, NOTCH1, ZBTB2, ZNF384, RUNX2, CDK6, GATA4, OSR2, ZNF184, ARNT, PBX4, NRF1, NFIB, DAXX, ATF2, HMGB2, ZNF518A, SOX11, PBX3, FOXM1, ETV6, FOS, CDK8, CHD1, MAFB, MED1, TEAD3, ZEB1, ZNF558, MYB, SCRT2, ZXDB, CEBPD, C11orf30, TBX5, EVI1, STAT5A, SETDB1, USF1, NIPBL, BCL11A, SP1, HNF4A, NR4A1, MAFK, ARID2, REST, ATF7, HNRNPLL, PHIP, TCF3, BCOR, PRDM6, SMC3, MLLT1, STAG2, STAG1, ZNF394, SKI, ZNF283, MEF2B, PPARG, FOXA2, CBX3, CREM, MEIS1, SS18, PAF1, ZNF600, ZNF692, GTF2B, WT1, ZSCAN16, EBF1, FOXF1, MEF2C, ZBTB33, CDK9, HOXB13, KDM1A, YY1, RELA, TARDBP, ZNF222, JUNB, TCF4, HIF1A, SKIL, ZIC2, BHLHE22, GATA3, BATF, TAL1, MAX, SPIB, ZNF143, GATA1, HAND2, KLF4, ZFP69B, SP7, NR2F2, TCF7L2, NEUROG2, KDM5B, TP53, MED, ZNF334, BCL6B, NFKB1, EGR2, ELF3, BRD2, BHLHE40, AR, TAF1, ZBTB16, RXR, ZNF324, ZNF366, EGR1, ZBTB26, HSF1, IKZF2, JUND, BRD4, NCOR1, SCRT1, RNF2, MAZ, ZSCAN23, FOSL2

Target gene symbol (double-evidenced CRMs): CLIC6,RUNX1,SETD4,RCAN1,SMIM11A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00418252