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Basic information

CohesinDB ID: CDBP00418261

Locus: chr21-35974854-35975595

Data sourse: GSE67783, GSE129526, GSE206145-NatGen2015, GSE68388, GSE25021

Cell type: MCF-7, Fibroblast, HCT-116, HSPC, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 86% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 44%, "14_ReprPCWk": 42%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, PGR, ZNF496, HMG20A, SOX2, NME2, FOXA1, RXRB, MLL4, ZFHX2, TFAP4, ATF3, CDX2, KLF5, TEAD1, KLF6, ESR1, HNF1B, JUN, TCF12, EP300, SOX9, SOX5, GATA6, TRIM24, TEAD4, FOXA3, ZNF175, GATAD2A, PDX1, TFAP2C, RBPJ, POU5F1, SAP130, ARID3A, HOXC5, ASCL1, MYC, ONECUT1, ARID1B, HOMEZ, RAD21, GRHL3, PROX1, NKX2-1, STAT3, XRCC5, APC, NKX3-1, ZNF614, RCOR1, NR2F6, CEBPB, EZH2, ZNF652, IRF1, HDAC2, GATA2, FLI1, ZGPAT, NFIL3, NCOA2, ETV5, CTNNB1, BCL6, CEBPA, NKX2-2, SOX13, SIN3A, SMAD3, RARA, CREBBP, ZNF384, RUNX2, GATA4, PBX4, ZNF48, SMAD4, CBFA2T3, FOS, CDK8, HMGXB4, TEAD3, KLF16, NIPBL, SP1, HNF4A, PHIP, FOXP1, NCOR2, STAG1, CBFA2T2, FOXA2, MIER2, ZNF662, TCF7, KDM1A, RELA, GATA3, TAL1, MAX, NRIP1, GATA1, KLF4, CEBPG, GFI1B, NR2F2, NCOA3, TCF7L2, TP53, MYOD1, EGR2, ELF3, ARID4B, AR, EGR1, RNF2, JUND, BRD4, CUX1, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): CLIC6,CBR1,RUNX1,SETD4,SMIM11A,RCAN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917, ENSG00000159228,

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Deatailed information for cohesin site CDBP00418261