- Basic information
- CohesinDB ID: CDBP00418267
- Locus: chr21-35984558-35985494
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, GSE111537, GSE25021, GSE108869, ENCSR000EDW, GSE115602, ENCSR917QNE, ENCSR000BTU, GSE67783, GSE138405, GSE76893, GSE116344, ENCSR703TNG, GSE145327, ENCSR000EEG, ENCSR338DUC, ENCSR000BLS, ENCSR000ECE, ENCSR000BMY, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE129526, ENCSR054FKH, GSE68388, GSE126990, GSE50893
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Cell type: RH4, GM2610, GM19240, Liver, HuCC-T1, H9-hESC, GM2630, Ishikawa, HeLa-S3, GM18486, H1-hESC, MB157, GM12878, GM12891, SK-N-SH, GM19239, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, Hep-G2, GM19238, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 16% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.722
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"14_ReprPCWk": 50%,
"15_Quies": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, PGR, HMG20A, HNF1A, XBP1, FOXA1, RXRB, KDM3A, HNRNPK, ZFP64, MXD4, SMARCE1, TEAD1, KLF6, RCOR2, ESR1, HNF1B, ZNF217, USF2, CTCF, TCF12, EP300, BAF155, SOX5, RAD51, TEAD4, FOXA3, ZNF175, GATAD2A, RBPJ, MLX, CHD8, POU5F1, ZNF317, ZBTB48, GATAD1, SAP130, ARID3A, TBP, ERG, MYC, ONECUT1, HOMEZ, RAD21, RXRA, NKX2-1, STAT3, ZNF614, XRCC5, NKX3-1, MIER3, NR2F6, NR3C1, CREB1, TBL1XR1, EZH2, GRHL2, ZNF652, SPI1, HBP1, TFE3, MIXL1, HDAC2, ZNF644, MXD3, DRAP1, ZGPAT, NFIL3, NCOA2, ETV5, THAP11, BCL6, SMC1A, CEBPA, SOX13, ZFX, TBX3, SP5, SMARCC1, RARA, ZNF384, NFYC, CREBBP, ZBTB2, ARNT, ZNF48, SMAD4, HMGXB4, TEAD3, ZMYM3, PIAS1, USF1, SP1, HNF4A, IKZF5, ASH2L, HNRNPLL, FOXP1, SMC3, STAG1, ETV4, SKI, PPARG, FOXA2, CREM, MIER2, TCF7, ZNF580, KDM1A, YY1, RELA, AHR, HIF1A, GATA3, MAX, PLAG1, CEBPG, NR2F2, KDM5B, ELF3, PHF5A, KAT8, ARID4B, NFKBIZ, BHLHE40, AR, EGLN2, ZBTB26, JUND, BRD4, CUX1, DMAP1, FOSL2
- Target gene symbol (double-evidenced CRMs): RUNX1,CLIC6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000159212,
ENSG00000159216,
- Related loop:
chr21:34700000-34725000~~chr21:35975000-36000000,
chr21:34850000-34875000~~chr21:35975000-36000000,
chr21:34875000-34900000~~chr21:35975000-36000000,
chr21:34950000-34975000~~chr21:35975000-36000000,
chr21:35507719-35509586~~chr21:35984012-35986224,
chr21:35507734-35509545~~chr21:35984106-35986257,
chr21:35850000-35875000~~chr21:35975000-36000000,
chr21:35875000-35900000~~chr21:35975000-36000000,