- Basic information
- CohesinDB ID: CDBP00418269
- Locus: chr21-35989141-35989875
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Data sourse: GSE206145-NatGen2015, ENCSR054FKH, GSE67783, GSE72082
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Cell type: Fibroblast, HSPC, Hep-G2
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: Mau2,SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"14_ReprPCWk": 38%,
"15_Quies": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, XBP1, FOXA1, HLF, RXRB, LYL1, MXD4, SMARCE1, MITF, JMJD1C, ETV1, LMO2, ESR1, RCOR2, JUN, CTCF, BAF155, GATA6, SOX5, KMT2B, FOXA3, GATAD2A, RBPJ, MYCN, HHEX, DUX4, SAP130, SP4, ERG, ETS1, MYC, SMARCA4, EOMES, HOMEZ, RAD21, GRHL3, NKX2-1, GABPA, NR2F6, NR3C1, ESRRA, CEBPB, KMT2A, EZH2, GABPB1, ZHX2, SPI1, GATA2, ZNF644, FLI1, NFIL3, NCOA2, ETV5, RUNX1, CEBPA, SOX13, ZFX, CBX8, CREBBP, ZNF384, RARA, RUNX2, CDK6, GATA4, ARNT, SOX11, ZNF48, SMAD4, CDK8, MED1, TEAD3, CEBPD, MYB, BCL11A, NR4A1, HNF4A, IKZF5, ASH2L, FOXP1, NCOR2, STAG1, SKI, FOXA2, WT1, MEF2C, HOXB13, KDM1A, RELA, HIF1A, GATA3, TAL1, MAX, NRIP1, CBX2, CEBPG, NCOA3, NR2F2, ELF3, T, AR, ZBTB26, MAZ
- Target gene symbol (double-evidenced CRMs): CLIC6,RUNX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000159212,
ENSG00000159216,
- Related loop:
chr21:34700000-34725000~~chr21:35975000-36000000,
chr21:34850000-34875000~~chr21:35975000-36000000,
chr21:34875000-34900000~~chr21:35975000-36000000,
chr21:34950000-34975000~~chr21:35975000-36000000,
chr21:35507719-35509586~~chr21:35984012-35986224,
chr21:35507734-35509545~~chr21:35984106-35986257,
chr21:35850000-35875000~~chr21:35975000-36000000,
chr21:35875000-35900000~~chr21:35975000-36000000,