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Basic information

CohesinDB ID: CDBP00418281

Locus: chr21-36023653-36025675

Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE165895

Cell type: RPE, Fibroblast, HCT-116, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 51%, "5_TxWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PAX7, FOXO1, PGR, CHD8, BRD1, FOXA2, MYCN, SS18, ZFX, ZNF30, ZBTB48, WT1, FOXF1, FOXA1, ZSCAN5A, CBX8, SUZ12, ERG3, DDX5, HOXB13, SMARCC1, ERG, KDM1A, RELA, YY1, ZNF384, ATF3, MYC, RUNX2, RAD21, MCM3, ARNT, GRHL3, HIF1A, TCF4, NRF1, SP140, PBX3, TP63, XRCC5, ZNF143, RCOR1, HAND2, MED1, CBX2, NR3C1, CEBPB, KLF4, NCOA3, TEAD3, ELF1, KMT2A, ETV1, SNAI2, SCRT2, EZH2, KDM5B, ESR1, CREB1, ZNF334, TBX5, EBF3, PHOX2B, CTCF, TCF12, JUN, SPI1, EP300, AR, GATA2, FLI1, SCRT1, MAZ, AATF, SMC3, STAG1, FOSL2

Target gene symbol (double-evidenced CRMs): RCAN1,CLIC6,RUNX1,SMIM11A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 7

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216,

eachgene

Deatailed information for cohesin site CDBP00418281