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Basic information

CohesinDB ID: CDBP00418283

Locus: chr21-36035088-36035988

Data sourse: ENCSR000BLD, GSE72082, ENCSR000BLY, GSE105028, GSE25021, GSE131606, GSE67783, ENCSR000BKV, GSE86191, GSE101921, GSE116344, GSE145327, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR167MTG, GSE129526, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, ENCSR000ECS

Cell type: RPE, H1-hESC, HCT-116, RH4, Hep-G2, HCAEC, DKO, HeLa-S3, HUES64, RT-112, SK-N-SH, K-562, HSPC, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 8% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: SMC3,Rad21,SA1,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 57%, "5_TxWk": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, HDGF, IKZF3, PAX5, ZNF320, TEAD1, ZNF121, OCA2, PITX3, HDAC8, SOX5, DEK, E2F4, ZNF528, GATAD2A, NANOG, ZNF263, POU5F1, CTBP1, STAT1, ZNF563, SAP130, ERG, EZH1, SMARCA4, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, KLF17, GATA2, MXD3, FLI1, HCFC1, DRAP1, MXI1, RUNX1, CEBPA, NKX2-2, HDAC1, ZNF654, TET2, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, TFDP1, ZBTB10, ATF2, SMARCB1, TERF1, PML, SMAD1, MBD1, STAT5A, IKZF5, ARID2, ELL2, CBFA2T2, MEF2B, CBX3, CREM, CHD2, SS18, PAF1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZFP36, TCF4, BATF, PLAG1, ZFP69B, BCL11B, ZBTB6, EGR2, ELF3, ARID4B, EGLN2, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, PBX2, ATF3, THRB, RUNX3, TP63, MITF, JMJD1C, ELF1, RBM39, JUN, CTCF, MNT, LMO1, DPF2, IRF4, PDX1, RBPJ, TFAP2C, ZSCAN21, ZBTB17, ZBTB48, ZNF317, SRF, DDX5, NBN, ZNF2, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, TERF2, LEF1, NR3C1, KMT2A, CCAR2, TBL1XR1, KLF8, EBF3, SMARCA5, NFIL3, THAP11, LDB1, SOX13, AFF4, ZNF770, ZMIZ1, ZNF18, ARNT, ZNF48, ZEB2, NFYA, PBX3, HMGXB4, TEAD3, KLF9, TBX5, USF1, BCL11A, SP1, NKX2-5, ATF7, ASH2L, GLIS2, SMC3, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MEIS1, MAFF, ZNF580, ZKSCAN1, KDM1A, ISL1, ZIC2, GATA3, TAL1, ZNF143, MTA1, AGO2, CBX2, TP53, ZSCAN22, PHOX2B, BRD2, PHF5A, KAT8, EGR1, RB1, RNF2, JUND, BRD4, CUX1, ZSCAN23, TBX2, PGR, PATZ1, LEO1, UBTF, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, KLF1, ZNF260, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, TBP, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, GFI1, DNMT3B, SRSF3, EZH2, ZNF652, SPI1, HDAC2, NFYB, ZNF554, ZNF76, ETV5, BCL6, SIN3A, ERG3, MEF2A, ZNF35, ZNF384, NFYC, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, SREBF2, ZNF22, RBM22, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, NCOR2, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, RELA, TARDBP, MAX, GFI1B, NR2F1, KDM5B, MYOD1, AR, PAX3-FOXO1, AHR, ZNF391, HMG20A, SUZ12, RBFOX2, ZFHX2, NFIC, CTCFL, PRDM1, BCLAF1, TRIM28, USF2, TCF12, EP300, BAF155, GATA6, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, EHMT2, EED, CHD8, BRD1, MYCN, CDK7, ID3, ZNF205, GATAD1, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF667, ZNF639, JMJD6, TFE3, IRF1, ZGPAT, MRTFB, ZC3H11A, ATF1, PTBP1, SMC1A, CBX1, ZFX, SMAD3, TWIST1, IRF2, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, FOS, CHD1, SUPT5H, MED1, CEBPD, MYB, SCRT2, ZNF3, L3MBTL2, NIPBL, PHF20, ZBTB7A, PHIP, TCF3, ZNF283, FOXA2, RBBP5, ZNF600, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, GATA1, HAND2, CEBPG, SP7, NR2F2, BHLHE40, NFKBIZ, MYNN, NOTCH3, CLOCK, MAZ

Target gene symbol (double-evidenced CRMs): RCAN1,SMIM11A,RUNX1,CLIC6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 27

Number of somatic mutations (non-coding): 9

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216,

eachgene

Deatailed information for cohesin site CDBP00418283