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Basic information

CohesinDB ID: CDBP00418287

Locus: chr21-36040874-36041598

Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, GSE86191

Cell type: RPE, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 70%, "5_TxWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, POU2F2, BCL6, CHD8, ZSCAN5D, ZNF263, POU5F1, SMC1A, MYCN, ZFX, ZNF600, XBP1, ZBTB17, ZBTB48, WT1, ZSCAN5A, PAF1, FOXA1, TET2, ERG3, PRDM10, ERG, YY1, RELA, EZH1, SP140, ARNT, HIF1A, ZIC2, GRHL3, CTNNB1, PBX4, ATF2, NKX2-1, NKX3-1, ZNF143, DNMT3B, PDX1, SCRT2, CREB1, EZH2, ESR1, OCA2, USF2, CTCF, RBM22, AR, FOXA2, ATF7, SCRT1, JUND, STAG1, TFAP2C

Target gene symbol (double-evidenced CRMs): CLIC6,RUNX1,SMIM11A,SETD4,RCAN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 6

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917,

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Deatailed information for cohesin site CDBP00418287