- Basic information
- CohesinDB ID: CDBP00418318
- Locus: chr21-36104103-36105761
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Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE126634, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE25021, ENCSR000EDW, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE115250, GSE138405, GSE67783, GSE86191, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, GSE120943, GSE112028, GSE130135, GSE116344, GSE106870, GSE138105, GSE145327, GSE94872, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE55407, GSE105004, ENCSR167MTG, GSE131956, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE38411
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, THP-1, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, GM19238, HeLa, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 31% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.378
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 23%,
"13_ReprPC": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, NANOG, SMC1A, BRD1, CHD8, EZH2phosphoT487, RBBP5, SIN3A, NME2, SMAD3, FOXA1, SRF, ZNF596, YY1, ZBTB2, CREBBP, JUNB, KDM4A, CTCFL, RAD21, CHD7, RUNX3, ATF2, FOXM1, XRCC5, MAX, ZNF143, CHD1, CEBPB, MAF, GFI1B, ELF1, TRIM28, STAG1, EZH2, T, CTCF, JUN, ZHX2, USF1, EP300, BCL11A, BRD2, TAF1, HDAC2, REST, ZBTB7A, E2F6, ASH2L, BRD4, CTBP2, JUND, MAZ, SMC1, SMC3, STAG2, TFAP2C
- Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A,CLIC6,SETD4
- Function elements
- Human SNPs: Blood_protein_levels
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000159212,
ENSG00000159216,
ENSG00000185917,
- Related loop:
chr21:34325000-34350000~~chr21:36075000-36100000,
chr21:34350000-34375000~~chr21:36075000-36100000,
chr21:34350000-34375000~~chr21:36100000-36125000,
chr21:34675000-34700000~~chr21:36100000-36125000,
chr21:34875000-34900000~~chr21:36100000-36125000,
chr21:35850000-35875000~~chr21:36100000-36125000,
chr21:35925000-35950000~~chr21:36100000-36125000,
chr21:35950000-35975000~~chr21:36075000-36100000,
chr21:35950000-35975000~~chr21:36100000-36125000,
chr21:36038258-36039755~~chr21:36103947-36105791,
chr21:36059285-36061312~~chr21:36104007-36105819,
chr21:36059311-36061185~~chr21:36103004-36105170,
chr21:36059312-36061200~~chr21:36104038-36105851,
chr21:36059347-36061711~~chr21:36102970-36104752,
chr21:36059348-36061289~~chr21:36103921-36105755,
chr21:36059613-36061297~~chr21:36103944-36105869,
chr21:36075000-36100000~~chr21:36175000-36200000,
chr21:36075000-36100000~~chr21:38250000-38275000,