- Basic information
- CohesinDB ID: CDBP00418320
- Locus: chr21-36111138-36114564
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, T-47D, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, CNCC-WT33iPSC, TC-71, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 81% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.133
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 25%,
"15_Quies": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: POU2F2, POU5F1, ZNF263, ZFX, XBP1, WT1, YY1, RELA, NFIC, NRF1, HIF1A, SMC3, APC, ETV6, MAX, ZNF143, ESRRA, KDM5B, ESR1, OCA2, GSPT2, AR, BRD4, CLOCK, TEAD4, TFAP2C
- Target gene symbol (double-evidenced CRMs): RUNX1,SETD4,SMIM11A,CBR1,CLIC6
- Function elements
- Human SNPs: Lumbar_spine_bone_mineral_density
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 23
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000159212,
ENSG00000159216,
ENSG00000185917,
ENSG00000159228,
- Related loop:
chr21:34350000-34375000~~chr21:36100000-36125000,
chr21:34675000-34700000~~chr21:36100000-36125000,
chr21:34875000-34900000~~chr21:36100000-36125000,
chr21:35839536-35841080~~chr21:36112039-36113944,
chr21:35850000-35875000~~chr21:36100000-36125000,
chr21:35925000-35950000~~chr21:36100000-36125000,
chr21:35931786-35934458~~chr21:36111989-36114651,
chr21:35950000-35975000~~chr21:36100000-36125000,
chr21:36027315-36029474~~chr21:36112024-36114058,
chr21:36027381-36029536~~chr21:36112029-36113907,
chr21:36027554-36029658~~chr21:36112019-36114026,
chr21:36045268-36046896~~chr21:36112056-36113996,
chr21:36052399-36053789~~chr21:36111955-36113883,
chr21:36058447-36061428~~chr21:36111897-36113834,
chr21:36059236-36061877~~chr21:36111989-36114651,
chr21:36059285-36061312~~chr21:36112056-36113996,
chr21:36059311-36061185~~chr21:36112033-36114031,
chr21:36059348-36061289~~chr21:36112009-36113920,
chr21:36059365-36061258~~chr21:36112039-36113944,
chr21:36059394-36061226~~chr21:36112056-36114424,
chr21:36069440-36070708~~chr21:36112102-36113990,