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Basic information

CohesinDB ID: CDBP00418325

Locus: chr21-36127229-36128557

Data sourse: GSE110061, GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 37%, "15_Quies": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, ADNP, NFIA, PGR, HMG20A, SOX2, NME2, XBP1, FOXA1, PBX2, ZFHX2, HNRNPK, ATF3, ZFP64, ZNF362, RUNX3, CHD7, ZNF444, CBFB, TP63, HDAC3, ZNF467, MAF, JMJD1C, KLF5, TEAD1, TRIM28, BCLAF1, KLF6, SNAI2, NFE2L2, LMO2, ESR1, ZNF217, OCA2, TP73, CTCF, JUN, TCF12, BAF155, KLF1, MNT, ZBTB20, SOX5, GATA6, DPF2, E2F6, IRF4, DEK, ZNF528, ZNF280A, TEAD4, FOXA3, ZNF92, PDX1, TFAP2C, EED, POU2F2, NANOG, CHD8, BRD3, POU5F1, CDK7, MYCN, ZNF263, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZSCAN5A, SRF, DDX5, ERG2, HNF4G, ERG, CHD4, ASCL1, NFKB2, ETS1, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, IKZF1, RCOR1, NFE2, ZNF639, NR3C1, ESRRA, CEBPB, CREB1, EZH2, BMPR1A, GRHL2, ZHX2, SPI1, MIXL1, HDAC2, GATA2, ZNF182, SIX2, FLI1, SMARCA5, RELB, NCOA2, RUNX1, THAP11, SMC1A, MAFG, CEBPA, NKX2-2, LDB1, CRY1, SIN3A, ZFX, POU4F2, EZH2phosphoT487, ZNF335, SMAD3, ZNF770, ERG3, CBX8, TRIM22, TWIST1, SMARCC1, ZNF18, PRDM10, ZBTB2, ZNF35, NOTCH1, CREBBP, ZNF384, RUNX2, GATA4, OSR2, ARNT, PBX4, DAXX, ZEB2, NFYA, ETV6, FOS, HMGXB4, CDK8, MED1, MYB, SCRT2, ZNF331, PIAS1, ZNF680, ZMYM3, EVI1, KLF16, ZNF22, MAFK, BCL11A, SP1, HNF4A, ARID1A, RBM25, ASH2L, PHIP, TCF3, FOXP1, BCOR, SMC3, ELL2, STAG2, STAG1, PPARG, FOXA2, CBX3, CREM, EBF1, ZNF600, ZSCAN16, GTF2B, WT1, FOXF1, ZNF574, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, AHR, ZNF148, BRG1, MCM3, TCF4, HIF1A, GATA3, BATF, MAX, NRIP1, ZNF143, GATA1, PLAG1, CBX2, KLF4, TLE3, CEBPG, NCOA3, NR2F2, NR2F1, TP53, NFKB1, MYOD1, EGR2, ZSCAN22, BRD2, ELF3, TBX21, AR, ZNF324, EGLN2, ZBTB42, TFIIIC, ZBTB26, IKZF2, BRD4, ILF3, SCRT1, NR1H3, MAZ, ZFP42, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): MORC3,HLCS,CHAF1B,SMIM11A,SIM2,DOP1B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 10

Related genes and loops

Related gene: ENSG00000205670, ENSG00000142197, ENSG00000159256, ENSG00000159259, ENSG00000159263, ENSG00000159267,

eachgene

Deatailed information for cohesin site CDBP00418325