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Basic information

CohesinDB ID: CDBP00418327

Locus: chr21-36129740-36130699

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, GSE126634, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, ENCSR330ELC, GSE108869, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE143937, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, GSE130135, ENCSR703TNG, ENCSR895JMI, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR807WAC, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, GSE55407, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE110061, GSE129526, ENCSR676MJK, GSE111913, GSE155324, GSE38411, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR153HNT, GSE68388, GSE50893, GSE126755, ENCSR000ECS, GSE131577

Cell type: MDM, GM2610, OCI-AML-3, HSPC, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, BCBL-1, K-562, HFFc6, DKO, H1-hESC, Monocytes, MB157, Lymphoblast, GM12878, GM2588, SK-N-SH, RT-112, THP-1, Macrophage, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, A-549, HCAEC, Neutrophil, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 29% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.578

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "1_TssA": 26%, "7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, ADNP, NFIA, PGR, HMG20A, SOX2, NME2, XBP1, FOXA1, PBX2, ZFHX2, HNRNPK, ATF3, ZFP64, ZNF362, RUNX3, CHD7, ZNF444, CBFB, TP63, HDAC3, ZNF467, MAF, JMJD1C, KLF5, TEAD1, TRIM28, BCLAF1, KLF6, SNAI2, NFE2L2, LMO2, ESR1, ZNF217, OCA2, TP73, CTCF, JUN, TCF12, BAF155, KLF1, MNT, ZBTB20, SOX5, GATA6, DPF2, E2F6, IRF4, DEK, ZNF528, ZNF280A, TEAD4, FOXA3, ZNF92, PDX1, TFAP2C, EED, POU2F2, NANOG, CHD8, BRD3, POU5F1, CDK7, MYCN, ZNF263, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZSCAN5A, SRF, DDX5, ERG2, HNF4G, ERG, CHD4, ASCL1, NFKB2, ETS1, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, IKZF1, RCOR1, NFE2, ZNF639, NR3C1, ESRRA, CEBPB, CREB1, EZH2, BMPR1A, GRHL2, ZHX2, SPI1, MIXL1, HDAC2, GATA2, ZNF182, SIX2, FLI1, SMARCA5, RELB, NCOA2, RUNX1, THAP11, SMC1A, MAFG, CEBPA, NKX2-2, LDB1, CRY1, SIN3A, ZFX, POU4F2, EZH2phosphoT487, ZNF335, SMAD3, ZNF770, ERG3, CBX8, TRIM22, TWIST1, SMARCC1, ZNF18, PRDM10, ZBTB2, ZNF35, NOTCH1, CREBBP, ZNF384, RUNX2, GATA4, OSR2, ARNT, PBX4, DAXX, ZEB2, NFYA, ETV6, FOS, HMGXB4, CDK8, MED1, MYB, SCRT2, ZNF331, PIAS1, ZNF680, ZMYM3, EVI1, KLF16, ZNF22, MAFK, BCL11A, SP1, HNF4A, ARID1A, RBM25, ASH2L, PHIP, TCF3, FOXP1, BCOR, SMC3, ELL2, STAG2, STAG1, PPARG, FOXA2, CBX3, CREM, EBF1, ZNF600, ZSCAN16, GTF2B, WT1, FOXF1, ZNF574, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, AHR, ZNF148, BRG1, MCM3, TCF4, HIF1A, GATA3, BATF, MAX, NRIP1, ZNF143, GATA1, PLAG1, CBX2, KLF4, TLE3, CEBPG, NCOA3, NR2F2, NR2F1, TP53, NFKB1, MYOD1, EGR2, ZSCAN22, BRD2, ELF3, TBX21, AR, ZNF324, EGLN2, ZBTB42, TFIIIC, ZBTB26, IKZF2, BRD4, ILF3, SCRT1, NR1H3, MAZ, ZFP42, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): CHAF1B,SMIM11A,MORC3,SIM2,CBR3,HLCS,DOP1B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 13

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159231, ENSG00000142197, ENSG00000159256, ENSG00000159259, ENSG00000159263, ENSG00000159267,

eachgene

Deatailed information for cohesin site CDBP00418327