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Basic information

CohesinDB ID: CDBP00418328

Locus: chr21-36132348-36133044

Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE111913, ENCSR153HNT

Cell type: MCF-7, HCT-116, RT-112, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: Mau2,SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 50%, "14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, FOSL1, MAFG, ZSCAN5D, EZH2phosphoT487, MYCN, ZFX, ZBTB17, ZBTB48, MAFF, STAT1, FOXA1, CBX8, RELA, IRF2, AHR, ZFP36, NRIP1, ZNF143, CBX2, ELF1, ESR1, C11orf30, TCF12, MAFK, SPI1, AR, GATA6, INTS13, RNF2, BRD4, PHIP, ZNF766, MAZ, ZNF316

Target gene symbol (double-evidenced CRMs): CBR3,HLCS,SMIM11A,DOP1B,CHAF1B,SIM2,MORC3

Function elements

Human SNPs: Height

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 29

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159231, ENSG00000142197, ENSG00000159256, ENSG00000159259, ENSG00000159263, ENSG00000159267,

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Deatailed information for cohesin site CDBP00418328