- Basic information
- CohesinDB ID: CDBP00418329
- Locus: chr21-36133297-36137447
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Data sourse: ShirahigeLab-GSE177045, GSE104888, GSE72082, GSE126634, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, GSE165895, ENCSR000EFJ, GSE67783, GSE86191, GSE138405, GSE101921, ShirahigeLab-NatGen2015, GSE120943, ENCSR198ZYJ, GSE130135, GSE116344, ENCSR703TNG, GSE118494, GSE98367, ShirahigeLab, ENCSR000BTQ, ENCSR853VWZ, GSE110061, GSE111913, ENCSR153HNT, GSE68388, GSE83726, ENCSR000ECS, GSE38411
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Cell type: MDM, RH4, HuCC-T1, H9-hESC, RPE, Fibroblast, HeLa-S3, IMR-90, K-562, BCBL-1, HFFc6, DKO, Monocytes, MB157, SK-N-SH, RT-112, HAP1, Macrophage, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Neurons-H1, A-549, HCAEC, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 17% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.700
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
92% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"2_TssAFlnk": 19%,
"5_TxWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, FOSL1, MAFG, ZSCAN5D, EZH2phosphoT487, MYCN, ZFX, ZBTB17, ZBTB48, MAFF, STAT1, FOXA1, CBX8, RELA, IRF2, AHR, ZFP36, NRIP1, ZNF143, CBX2, ELF1, ESR1, C11orf30, TCF12, MAFK, SPI1, AR, GATA6, INTS13, RNF2, BRD4, PHIP, ZNF766, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): CBR3,HLCS,SIM2,DOP1B,SMIM11A,MORC3,CHAF1B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 63
- Number of somatic mutations (non-coding): 73
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000159231,
ENSG00000142197,
ENSG00000159256,
ENSG00000159259,
ENSG00000159263,
ENSG00000159267,
- Related loop:
chr21:27500000-27525000~~chr21:36125000-36150000,
chr21:34350000-34375000~~chr21:36125000-36150000,
chr21:36122381-36123542~~chr21:36140871-36142703,
chr21:36122898-36124126~~chr21:36134610-36136702,
chr21:36125000-36150000~~chr21:36225000-36250000,
chr21:36125000-36150000~~chr21:36300000-36325000,
chr21:36125000-36150000~~chr21:36325000-36350000,
chr21:36125000-36150000~~chr21:36350000-36375000,
chr21:36125000-36150000~~chr21:36375000-36400000,
chr21:36125000-36150000~~chr21:36500000-36525000,
chr21:36125000-36150000~~chr21:36575000-36600000,
chr21:36125000-36150000~~chr21:36625000-36650000,
chr21:36125000-36150000~~chr21:36675000-36700000,
chr21:36125000-36150000~~chr21:36900000-36925000,
chr21:36125000-36150000~~chr21:36925000-36950000,
chr21:36125000-36150000~~chr21:38150000-38175000,
chr21:36125000-36150000~~chr21:38325000-38350000,
chr21:36125000-36150000~~chr21:38350000-38375000,
chr21:36140628-36142797~~chr21:36208896-36211059,
chr21:36140628-36142797~~chr21:36329784-36332238,
chr21:36140628-36142797~~chr21:36388297-36390535,
chr21:36140648-36142704~~chr21:36389208-36390546,
chr21:36140770-36142598~~chr21:36208928-36210883,
chr21:36140783-36142792~~chr21:36329776-36331881,
chr21:36140783-36142792~~chr21:36388547-36390538,
chr21:36140789-36142775~~chr21:36208898-36210957,
chr21:36140789-36142775~~chr21:36329509-36332676,
chr21:36140792-36142611~~chr21:36208845-36210808,
chr21:36140792-36142611~~chr21:36330014-36331898,
chr21:36140799-36142667~~chr21:36329820-36331841,
chr21:36140799-36142837~~chr21:36208339-36210839,
chr21:36140799-36142837~~chr21:36329790-36332543,
chr21:36140808-36142792~~chr21:36208893-36211062,
chr21:36140808-36142792~~chr21:36389186-36390767,
chr21:36140808-36142792~~chr21:36419122-36421037,
chr21:36140818-36142825~~chr21:36208180-36210735,
chr21:36140822-36142823~~chr21:36208825-36210883,
chr21:36140822-36142823~~chr21:36329998-36331844,
chr21:36140824-36142795~~chr21:36208849-36210862,
chr21:36140824-36142795~~chr21:36329821-36332549,
chr21:36140824-36142795~~chr21:36389196-36390710,
chr21:36140824-36142795~~chr21:36419273-36421104,
chr21:36140828-36142593~~chr21:36208784-36210767,
chr21:36140829-36142646~~chr21:36389162-36390561,
chr21:36140830-36142847~~chr21:36329991-36331896,
chr21:36140830-36142847~~chr21:36389185-36390513,
chr21:36140835-36142753~~chr21:36388314-36390557,
chr21:36140836-36142645~~chr21:36208979-36210847,
chr21:36140837-36142525~~chr21:36208955-36210590,
chr21:36140837-36142525~~chr21:36330185-36331807,
chr21:36140837-36142525~~chr21:36389208-36390500,
chr21:36140838-36142714~~chr21:36208696-36210781,
chr21:36140838-36142724~~chr21:36330105-36331857,
chr21:36140838-36142786~~chr21:36208808-36211018,
chr21:36140838-36142786~~chr21:36329955-36332030,
chr21:36140838-36142786~~chr21:36388412-36390522,
chr21:36140843-36142531~~chr21:36208942-36210568,
chr21:36140848-36142815~~chr21:36208865-36210865,
chr21:36140848-36142815~~chr21:36329998-36332133,
chr21:36140849-36142584~~chr21:36208920-36210789,
chr21:36140850-36142837~~chr21:36208890-36210845,
chr21:36140850-36142837~~chr21:36329788-36331839,
chr21:36140851-36142527~~chr21:36330219-36331784,
chr21:36140852-36142557~~chr21:36208778-36210979,
chr21:36140852-36142574~~chr21:36330027-36331746,
chr21:36140857-36142570~~chr21:36330220-36331778,
chr21:36140862-36142780~~chr21:36208188-36210796,
chr21:36140863-36142602~~chr21:36208770-36210834,
chr21:36140866-36142633~~chr21:36208896-36210832,
chr21:36140866-36142633~~chr21:36330006-36331764,
chr21:36140870-36142745~~chr21:36209005-36210744,
chr21:36140870-36142745~~chr21:36330021-36331732,
chr21:36140871-36142703~~chr21:36208897-36210863,
chr21:36140871-36142703~~chr21:36330000-36331880,
chr21:36140877-36142726~~chr21:36330374-36331962,
chr21:36140896-36142511~~chr21:36330240-36331785,