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Basic information

CohesinDB ID: CDBP00418330

Locus: chr21-36138179-36138394

Data sourse: GSE206145-NatGen2015, ENCSR153HNT

Cell type: K-562, Fibroblast

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 65%, "14_ReprPCWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, FOXA1, MLL4, KDM3A, THAP1, ZBTB44, IKZF3, MORC2, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, ZNF561, ZNF577, DEK, E2F4, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, CTBP1, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, NFKB2, EZH1, SMARCA4, TOP1, ZNF398, RCOR1, NR2F6, CEBPB, CREB1, BMPR1A, GABPB1, ZHX2, KLF17, ZNF257, GATA2, MXD3, FLI1, HCFC1, MXI1, RELB, RUNX1, HDAC1, CEBPA, NKX2-2, REPIN1, ZNF549, PRDM10, SMARCC1, ZXDC, TFDP1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, PML, TERF1, PIAS1, NR1H2, C11orf30, GSPT2, ARID2, IKZF5, MBD2, ELL2, CBFA2T2, CREM, CHD2, SS18, NFATC1, PAF1, ZSCAN16, WT1, JUNB, ZFP36, MAF1, SPIB, PLAG1, ZFP69B, KLF4, BCL11B, ZBTB6, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, FOSL1, SMARCA2, ZNF660, XBP1, ZNF596, ATF3, ZFP64, CBFB, ZSCAN4, TP63, MITF, BACH2, ZNF467, MAF, JMJD1C, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, RYBP, DPF2, IRF4, ZNF423, ZNF350, PDX1, TFAP2C, RBPJ, ZSCAN21, ZBTB17, ZNF317, ZBTB48, MTA2, SRF, ZNF2, KDM4A, FOXP2, TSHZ1, RXRA, PRDM14, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, KLF8, GRHL2, EBF3, ZBTB14, SSRP1, ZNF146, THAP11, EZH2phosphoT487, LDB1, AFF4, SOX13, ZNF770, ZNF18, SP3, ARNT, BACH1, DAXX, ZNF48, PRDM9, ZEB2, PBX3, NCAPH2, ZNF10, ETV6, TEAD3, ZXDB, ZNF680, KLF9, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, PCGF2, CTBP2, GLIS2, PRDM6, SMC3, STAG1, STAG2, MLLT1, ZNF394, TRP47, AGO1, EBF1, MAFF, ESR2, ZNF580, KLF7, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, NFKB1, ZSCAN22, PHOX2B, BRD2, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, ZSCAN23, TBX2, PGR, SOX2, PATZ1, RING1B, CHD7, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, KLF1, ZNF695, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZSCAN5A, ZMYND8, ERG2, HIC1, SP4, HOXC5, OGG1, ETS1, MYC, ZNF24, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, EZH2, MRTFA, PHF8, SPI1, ZNF202, HDAC2, ZNF76, ZNF554, ETV5, BCL6, SIN3A, ERG3, CREBBP, ZNF35, RARA, NFYC, TAF15, ZNF384, ZNF518A, SMAD4, CBFA2T3, CDK8, CSNK2A1, ZEB1, SUPT16H, SREBF2, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, TBL1X, HDAC6, ZNF44, ZNF692, GTF2B, ZNF30, ZNF574, RELA, TARDBP, MAX, GFI1B, TCF7L2, NR2F1, KDM5B, PKNOX1, MYOD1, AR, YAP1, ZNF324, HEXIM1, AHR, FOSL2, MBD3, DMAP1, ZNF391, SUZ12, ZFHX2, SFMBT1, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, USF2, TCF12, BAF155, EP300, PRDM4, GLI4, E2F1, SMC1, TEAD4, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, CDK7, ID3, ASCL1, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, EHF, IRF1, ZGPAT, MRTFB, ZIM3, ATF1, SMC1A, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, CBX8, NOTCH1, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, CDK6, PBX4, NRF1, FOS, CHD1, SUPT5H, MED1, KDM6B, MYB, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, PHIP, TCF3, NELFA, FOXA2, RBBP5, ZNF600, ZBTB33, CDK9, HOXB13, YY1, ASXL1, ZNF610, SP140, HIF1A, OTX2, ZNF449, GATA1, SP7, NCOA3, NR2F2, ZNF687, ZNF213, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, NOTCH3, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): MORC3,CBR3,DOP1B,SMIM11A,HLCS,CHAF1B,SIM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159231, ENSG00000142197, ENSG00000159256, ENSG00000159259, ENSG00000159263, ENSG00000159267,

eachgene

Deatailed information for cohesin site CDBP00418330