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Basic information

CohesinDB ID: CDBP00418336

Locus: chr21-36149046-36149389

Data sourse: GSE138405, GSE67783, GSE98367

Cell type: Hela-Kyoto, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SMC3,SA1,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 92% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 59%, "15_Quies": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, CBX5, HMG20A, ZSCAN5C, ZNF660, MEIS2, XBP1, FOXA1, SUZ12, RXRB, PBX2, TFAP4, HDGF, LYL1, ZFP64, RUNX3, IKZF3, CBFB, MECOM, SMARCE1, PAX5, MITF, ZNF320, INTS11, JMJD1C, MAF, ELF1, ZNF121, TRIM28, ETV1, BCLAF1, NFE2L2, SMAD5, ESR1, MLL, LMO2, CTCF, TCF12, E4F1, LMO1, ZNF75A, DPF2, TRIM24, IRF4, SOX6, E2F1, ZNF350, TEAD4, KMT2B, GATAD2A, EHMT2, RBPJ, EED, POU2F2, CHD8, RUNX1T1, KDM4C, ID3, CTBP1, MTA2, ZBTB48, ZSCAN5A, STAT1, MLLT3, SAP130, TBP, ERG, HOXC5, ETS1, MYC, TRIP13, EZH1, ARID1B, RAD21, RXRA, NKX2-1, GABPA, STAT3, IKZF1, NFE2, RCOR1, NR2F6, CD74, VDR, CEBPB, ESRRA, KMT2A, ZBTB11, EZH2, GABPB1, PHF8, ELF4, SPI1, MIXL1, ZNF257, HDAC2, GATA2, INTS13, FLI1, DRAP1, NR2C2, RELB, NFYB, ATF1, RUNX1, BCL6, SMC1A, CEBPA, HDAC1, CBX1, SOX13, ZFX, ZNF770, TRIM22, RARA, ZNF384, CREBBP, RUNX2, GATA4, ARNT, HMGB2, SMAD4, HMBOX1, NFYA, ETV6, FOXM1, NR2C1, SUPT5H, HMGXB4, CDK8, SP2, FOS, MED1, ZEB1, TERF1, PML, MYB, TEAD3, ZMYM3, TAF7, ZNF3, L3MBTL2, EVI1, BCL11A, SP1, HNF4A, NR4A1, REST, ZBTB7A, ATF7, ASH2L, BCOR, TCF3, SMC3, MLLT1, STAG1, SKI, MEF2B, PPARG, CBX3, MTA3, CREM, FOXA2, NFATC1, GTF2B, ESR2, ZNF574, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, TCF4, ZFP36, GATA3, TAL1, MAX, SPIB, GATA1, NRIP1, CEBPG, GFI1B, NR2F2, TCF7L2, KDM5B, TP53, PKNOX1, ZNF687, MED, MYOD1, BRD2, AR, TAF1, ZBTB40, RXR, EGR1, RB1, HSF1, IKZF2, BRD4, ILF3, JUND

Target gene symbol (double-evidenced CRMs): MORC3,SMIM11A,HLCS,SIM2,CBR3,DOP1B,CHAF1B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159231, ENSG00000142197, ENSG00000159256, ENSG00000159259, ENSG00000159263, ENSG00000159267,

eachgene

Deatailed information for cohesin site CDBP00418336